Evidence map›Paper›PMID 40200948›Full record

ArticleJournal of biological methods2025

Platelet-rich plasma as a promising bioscaffold for enhancing peripheral nerve regeneration: An experimental study in a rat sciatic nerve model.

Sofija Pejkova, Velimir Stojkovski, Gordana Georgieva, Boris Aleksovski, Sofija Tusheva, Blagoja Srbov, Elena Rafailovska, Stefania Azmanova Mladenovska, Katerina Jovanovska, Bisera Nikolovska and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sofija PejkovaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Velimir StojkovskiFaculty of Veterinary Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Gordana GeorgievaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Boris AleksovskiInstitute for Biology, Faculty of Natural Sciences and Mathematics, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Sofija TushevaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Blagoja SrbovUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Elena RafailovskaInstitute for Biology, Faculty of Natural Sciences and Mathematics, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Stefania Azmanova MladenovskaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Katerina JovanovskaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Bisera NikolovskaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Boro IlievskiInstitute for Pathology, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Boro DzonovUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Trpe RistoskiFaculty of Veterinary Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Anita PetrushevskaUniversity Clinic for Plastic and Reconstructive Surgery, Faculty of Medicine, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.
Icko GjorgoskiInstitute for Biology, Faculty of Natural Sciences and Mathematics, University Ss Cyril and Methodius, Skopje 1000, North Macedonia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Despite advancements in surgical treatments, impairments persist after peripheral nerve injuries, prompting a shift in research toward the microenvironment of injured axons. Platelet-rich plasma (PRP), rich in growth factors and derived from autologous blood, emerges as a potential candidate to accelerate nerve healing. Objective: This study investigated the role of PRP in enhancing peripheral nerve regeneration using a rat sciatic nerve model ( Methods: A transected sciatic nerve model was created, with both hindlimbs repaired through end-to-end neurorrhaphy. PRP, prepared from the blood of a healthy Wistar rat, was applied to one hindlimb. Functional recovery was assessed using sciatic indices. At the 20-week time point, histological evaluations were performed to compare PRP-treated hindlimbs with control ones. Statistical analysis was conducted to compare the results between the two groups using three different calculations for specific parameters. Results: Walking track-based sciatic functional index (SFI) showed an improvement of 66.0%, 47.8%, and 71.6% ( Conclusion: This study demonstrated PRP's utility in promoting peripheral nerve regeneration, highlighting its potential for both fundamental research and clinical applications.

Indexed as

Experimental studyNerve repairPeripheral nerve regenerationPlatelet-rich plasmaSurgical techniques

Identifiers

PMID40200948
PMCPMC11973046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.