ArticleMolecular biology and evolution2025
Ectopic Gene Conversion Causing Quantitative Trait Variation.
Article in Molecular biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- DNA sandwich nanozyme-based colorimetric and photothermal biosensor for high-efficiency detection of fusion genes.Analytical and bioanalytical chemistry · 2026Article
- Convergence and constraint in glucosinolate evolution across the Brassicaceae.The Plant cell · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
Why is there so much non-neutral genetic variation segregating in natural populations? We dissect function and evolution of a near-cryptic quantitative trait locus (QTL) for defense metabolites in Arabidopsis using the CRISPR/Cas9 system and nucleotide polymorphism patterns. The QTL is explained by genetic variation in a family of 4 tightly linked indole-glucosinolate O-methyltransferase genes. Some of this variation appears to be maintained by balancing selection, some appears to be generated by non-reciprocal transfer of sequence, also known as ectopic gene conversion (EGC), between functionally diverged gene copies. Here, we elucidate how EGC, as an inevitable consequence of gene duplication, could be a general mechanism for generating genetic variation for fitness traits.
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