Evidence map›Paper›PMID 40200338›Full record

Trial reportJournal of neuroengineering and rehabilitation2025

Mechanical peripheral stimulation for the treatment of gait disorders in patients with Parkinson's disease: a multi-centre, double-blind, crossover randomized controlled trial.

Maria Francesca De Pandis, Carlo Tomino, Stefania Proietti, Rossella Rotondo, Maria Gaglione, Miriam Casali, Massimo Corbo, Lazzaro di Biase, Manuela Galli, Michela Goffredo and 1 more

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03843268 (Multi-center, Double-blind, Cross-over Randomized Study on the Use of the Medical Device "Gondola" for Motor Rehabilitation in Patients With Parkinson's Disease), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03843268 nacompletednot on this map

Multi-center, Double-blind, Cross-over Randomized Study on the Use of the Medical Device "Gondola" for Motor Rehabilitation in Patients With Parkinson's Disease

TypeinterventionalSponsorIRCCS San Raffaele RomaRan2017 to 2019Enrolled124ConditionsParkinson DiseaseArmsAMPS Gondola, Sham Gondola
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maria Francesca De PandisSan Raffaele Hospital Cassino, Via G. Di Biasio, 1, 03043, Cassino, Italy.
Carlo TominoIRCCS San Raffaele Roma, Via Della Pisana, 235-00163, Rome, Italy.
Stefania ProiettiIRCCS San Raffaele Roma, Via Della Pisana, 235-00163, Rome, Italy.
Rossella RotondoSan Raffaele Hospital Cassino, Via G. Di Biasio, 1, 03043, Cassino, Italy.
Maria GaglioneSan Raffaele Hospital Cassino, Via G. Di Biasio, 1, 03043, Cassino, Italy.
Miriam CasaliIRCCS San Raffaele Roma, Via Della Pisana, 235-00163, Rome, Italy.
Massimo CorboCasa di Cura del Policlinico Dezza, Milan, Italy.
Lazzaro di BiaseFondazione Policlinico Universitario Campus Bio-Medico, Operative Research Unit of Neurology, Rome, Italy.
Manuela GalliPolitecnico University, Milan, Italy.
Michela Goffredo *Department of Human Sciences and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy.
Fabrizio Stocchi *Department of Human Sciences and Promotion of Quality of Life, San Raffaele Open University, Rome, Italy. fabrizio.stocchi@sanraffaele.it.

Funding

Ministero della Salute Ricerca Corrente 2022
6 · The paper itself

Abstract

backgroundPharmacological, surgical and physical therapies ameliorate motor and non-motor symptoms in Parkinson's disease (PD). Unfortunately, the progression of the disease induces deterioration in daily activities, especially in gait and balance. Invasive and non invasive medical devices have been developed to alleviate drug-resistant symptoms in patients with advanced PD, and automated mechanical peripheral stimulation (AMPS) has been proposed as a new rehabilitative approach.

methodsThis multicentre, double-blind, crossover randomized controlled trial included 83 participants with PD assigned to two groups: AMPS treatment (Gondola

resultsThe Gondola

conclusionsAMPS stimulation improved gait speed in people with PD. Trial registration ClinicalTrials.gov identifier: NCT03843268. Date of registration: 12 Feb 2019, retrospectively registered.

Indexed as

Gait Disorders, NeurologicParkinson DiseaseAgedCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeWalking SpeedAMPSGait disordersGondola® deviceParkinson’s diseaseRehabilitation

Identifiers

PMID40200338
PMCPMC11978199

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.