Evidence map›Paper›PMID 40200298›Full record

ArticleBMC psychiatry2025

General polypharmacy, psychotropic polypharmacy, attitudes of patients on psychotropic deprescribing, and associated factors in adult psychiatric outpatients: a survey study in a comprehensive specialized hospital, northwest Ethiopia.

Muluken Adela Alemu, Taklo Simeneh Yazie, Woretaw Sisay Zewdu, Liknaw Workie Limenh, Tewodros Ayalew Tessema, Tirsit Ketsela Zeleke, Getu Tesfaw Adiss, Achenef Bogale Kassie, Getaye Tessema Desta, Abrham Nigussie Assefa and 1 more

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Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Muluken Adela AlemuDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia. muladal1234@gmail.com.
Taklo Simeneh YazieDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Woretaw Sisay ZewduDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Liknaw Workie LimenhDepartment of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O.Box +196, Gondar, Ethiopia.
Tewodros Ayalew TessemaDepartment of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O.Box +196, Gondar, Ethiopia.
Tirsit Ketsela ZelekeDepartment of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, P.O.Box +269, Debre Tabor, Ethiopia.
Getu Tesfaw AdissDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Achenef Bogale KassieDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Getaye Tessema DestaDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Abrham Nigussie AssefaDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.
Tilaye Arega MogesDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, P.O.Box +272, Debre Tabor, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExcessive polypharmacy causes different problems, including adverse drug reactions and drug-drug interactions. To address the problems, deprescribing has emerged, focusing on reducing the dose or stopping unnecessary medications.

objectiveThis study aimed to explore the prevalence of psychotropic polypharmacy, general polypharmacy, deprescribing attitudes and associated factors for psychotropic medications in adult patients with mental disorders. MATERIALS AND

methodsA facility-based cross-sectional survey study design was conducted to collect data on 123 patients with mental disorders from April 2022 to August 2024. Revised patients' attitudes towards deprescribing (rPATD), trust in physician score, and orientation memory concentration test were used. Descriptive statistics, one-way analysis of variance, and independent t-tests were used. P-value of 0.05 was a cutoff point to determine significant association.

resultsThe prevalence of general polypharmacy and psychiatric polypharmacy was 17.9% [22] and 29.3% [36] respectively. Near to half of patients (54, 44.7%) felt they were taking large number of medications; more than half (69, 56.1%) felt spending a lot of money. Patients with age of > 60 years had significant differences with patients aged from 18 to 44 (p < 0.001) and 45-59 (p < 0.01) years on burden and appropriateness domains respectively. Patients who took < 5 medications had significant difference (p < 0.001) with patients taking ≥ 5 medications on both burden and appropriateness domains.

conclusionThe findings of the study showed many patients had meaningful prevalence of general polypharmacy and psychotropic polypharmacy. Patients expressed diverse attitudes toward deprescribing, affected by different factors. This study is conducted in a single health facility with small sample size. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

DeprescriptionsHealth Knowledge, Attitudes, PracticeMental DisordersOutpatientsPolypharmacyPsychotropic DrugsAdolescentAdultAgedCross-Sectional StudiesEthiopiaFemaleHumansMaleMiddle AgedSurveys and QuestionnairesPsychotropic DrugsDeprescribingGeneral polypharmacyPsychotropic polypharmacyPsychotropics

Identifiers

PMID40200298
PMCPMC11980274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.