Evidence map›Paper›PMID 40200288›Full record

ArticleReproductive biology and endocrinology : RB&E2025

Associations between organophosphate flame retardants metabolites in follicular fluid and reproductive outcomes among women undergoing IVF/ICSI treatment in Southwest China.

Xiaohong Li, Jiahui Qiu, Zhiwei Gan, Shangwei Li, Xun Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaohong Li *Center for Reproductive Medicine, Department of Obstetrics and Gynecology & Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiahui Qiu *Center for Reproductive Medicine, Department of Obstetrics and Gynecology & Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhiwei GanCollege of Architecture and Environment, Sichuan University, Chengdu, Sichuan, China.
Shangwei LiCenter for Reproductive Medicine, Department of Obstetrics and Gynecology & Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Xun ZengCenter for Reproductive Medicine, Department of Obstetrics and Gynecology & Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. zx657@sina.com.

Funding

Department of Science and Technology of Sichuan Province 2024YFFK0328Department of Science and Technology of Sichuan Province 2024YFFK0366
6 · The paper itself

Abstract

backgroundPrevious studies suggest organophosphate flame retardants (OPFRs) negatively affect fertility, but limited research explores their metabolites in follicular fluid and reproductive outcomes.

objectivesTo investigate the associations between concentrations of OPFRs metabolites in follicular fluid and the outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) among women undergoing treatment.

methodsWomen who underwent IVF/ICSI treatment at the Reproductive Center of West China Second University Hospital, Sichuan University, China, from 2017 to 2020 were recruited. The levels of seven OPFRs metabolites were quantified in follicular fluid collected on the day of oocyte retrieval. Reproductive outcomes were assessed, including key IVF/ICSI outcomes.

resultsThis study included 401 women. After adjusting for relevant confounders, elevated concentrations of BBOEP (β = -0.08, 95% CI: -0.12 to 0 0.05), BEHP (β = -0.11, 95% CI: -0.17 to 0.05), DnBP (β = -0.23, 95% CI: -0.37 to 0.08), and DPhP (β = -0.12, 95% CI: -0.18 to 0.06) in follicular fluid were inversely associated with the number of good embryos on day 3. Elevated BEHP concentrations were negatively associated with the total number of oocytes (β = -0.04, 95% CI: -0.07 to 0.01). In comparison with the lowest tertile, the highest tertile of DnBP was associated with a 42% reduction in biochemical pregnancy (p-trend = 0.05). Furthermore, the BKMR models revealed inverse associations between OPFRs metabolites mixtures and the number of good embryos.

conclusionFindings suggest OPFRs may negatively affect IVF/ICSI outcomes, warranting further study on environmental impacts on fertility.

Indexed as

Fertilization in VitroFlame RetardantsFollicular FluidOrganophosphatesSperm Injections, IntracytoplasmicAdultChinaFemaleHumansPregnancyPregnancy OutcomePregnancy RateFlame RetardantsOrganophosphatesFollicular fluidOrganophosphate flame retardantsReproductive outcomes

Identifiers

PMID40200288
PMCPMC11977869

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.