Observational studyBMC ophthalmology2025
Clinical study of 37 cases of orbital melanoma.
Observational study in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Gastric Melanoma in A 19-Year-Old Patient: A Rare Case and A Review of Diagnostic Pitfalls.European journal of case reports in internal medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundTo analyze the clinical features and prognosis of orbital melanoma.
designRetrospective observational case series.
methodsA retrospective analysis of the electronic medical records, histopathology, imaging examinations, and follow-up information of 37 patients with orbital melanoma.
resultsThe most common primary site was the conjunctiva, with half of the patients presenting with orbital involvement at the initial visit. The most common symptoms were globe displacement due to intraorbital mass, causing swelling of the eyelids and blurred vision. All patients underwent mass excision surgery. Rates of intraorbital soft tissue infiltration, nerve invasion, and bone destruction were 48.6%, 18.9%, and 13.5%, respectively. Five patients (13.5%) have distant metastases to the liver, bones, lungs, skin, and parotid lymph nodes. The Median Survival Time of the 13 deceased patients was 132 ± 24.88 months, with a 5-year survival rate of 78.4%±7.3%. The presence of nerve invasion showed a significant correlation with prognosis (P = 0.047 < 0.05), while age, gender, eye involvement, bone destruction, and intraorbital soft tissue infiltration showed no significant correlation with prognosis (P > 0.05). The expression of Ki-67 was negatively correlated with patient survival time and rate, where higher Ki-67 expression was associated with shorter survival time (r
conclusionsTreatment strategies for orbital melanoma should consider the tumor's invasive characteristics and Ki-67 expression levels to optimize treatment outcomes and improve patient survival rates. Furthermore, due to the significant impact of nerve involvement on prognosis, it is recommended that clinical focus on this factor be enhanced.
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Registered trials
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