Case report: post COVID-19 encephalopathy and oral cenesthopathy.

Ju-I Wu, Shwu-Hua Lee, Pei-Jung Chen

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Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Ju-I WuDepartment of Psychiatry, Chang Gung Memorial Hospital, Linkou Branch, No.5, Fuxing St., Guishan Dist, Taoyuan, 333, Taiwan.

Shwu-Hua LeeDepartment of Psychiatry, Chang Gung Memorial Hospital, Linkou Branch, No.5, Fuxing St., Guishan Dist, Taoyuan, 333, Taiwan.

Pei-Jung ChenDepartment of Psychiatry, Chang Gung Memorial Hospital, Linkou Branch, No.5, Fuxing St., Guishan Dist, Taoyuan, 333, Taiwan. ddgacc.chen@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Post-COVID-19 encephalopathy is a neurological complication characterized by cognitive impairment, memory loss, and other neuropsychiatric symptoms in COVID-19 survivors. Oral cenesthopathy, a rare somatic delusion characterized by unusual oral sensations without physical findings, is typically associated with affective disorders and schizophrenia. This case report describes a 73-year-old female who developed post-COVID-19 encephalopathy, presenting initially with cognitive decline, followed by major depression and oral cenesthopathy 16 months after the infection. Comprehensive investigations excluded autoimmune encephalitis, Creutzfeldt-Jakob disease, and other structural or vascular abnormalities. Treatment with Aripiprazole and Carbamazepine resulted in partial improvement, though symptom control was limited by medication side effects. This case represents a rare presentation of long COVID syndrome, highlighting the complex neuropsychiatric sequelae of COVID-19. Further research is needed to explore the pathophysiology, treatment strategies, and long-term impacts of such manifestations.

Indexed as

Brain DiseasesCognitive DysfunctionCOVID-19DelusionsMajor Depressive DisorderAgedAripiprazoleCarbamazepineFemaleHumansSARS-CoV-2AripiprazoleCarbamazepineCase reportDelusional disorder somatic typeLong COVID syndromeOral cenesthopathyPost COVID-19 encephalopathy

Identifiers

PMID40200197

DOI10.1186/s12888-025-06789-1

PMCPMC11980331

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.