Evidence map›Paper›PMID 40200155›Full record

ArticleBMC infectious diseases2025

Invasive cerebral aspergillosis in a pregnant woman: a rare case of intracranial giant granuloma.

Zhiwei Zhou, Xueqin Hu, Jingwen Wang, Nianhua Wang

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhiwei ZhouDepartment of Neurosurgery, Xiangya School of Medicine, The First People's Hospital of Changde City, Central South University, Changde, Hunan, 415003, China.
Xueqin HuDepartment of Neurosurgery, Xiangya School of Medicine, The First People's Hospital of Changde City, Central South University, Changde, Hunan, 415003, China.
Jingwen WangDepartment of Obstetrics and Gynecology, Xiangya School of Medicine, The First People's Hospital of Changde City, Central South University, Changde, Hunan, 415003, China.
Nianhua WangDepartment of Neurosurgery, Xiangya School of Medicine, The First People's Hospital of Changde City, Central South University, Changde, Hunan, 415003, China. wnhlch1981@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive Cerebral Aspergillosis (ICA) is a rare fungal infection affecting the brain, primarily seen in individuals with compromised immune systems. Despite various treatment options, substantial cerebral granulomas caused by ICA still result in high mortality and recurrence rates. CASE PRESENTATION: We report a rare instance of ICA in a 30-year-old pregnant woman. The infection initiated in the nasal cavity and progressed to form a large intracranial granuloma, leading to brain herniation. Diagnosis was confirmed through histopathology, Polymerase Chain Reaction (PCR), and metagenomic next-generation sequencing (mNGS) following decompressive craniotomy and sinus window drainage surgery. Prompt administration of antifungal medication resulted in a favorable prognosis.

conclusionThis case highlights the critical roles of mNGS and PCR in the early diagnosis of ICA, as well as the pivotal importance of surgical interventions and prompt initiation of antifungal therapy in enhancing patient outcomes.

Indexed as

GranulomaNeuroaspergillosisPregnancy Complications, InfectiousAdultAntifungal AgentsBrainFemaleHigh-Throughput Nucleotide SequencingHumansPolymerase Chain ReactionPregnancyAntifungal AgentsCranial hypertensionGiant granulomaIntracranialInvasive aspergillus flavus infectionMetagenomic next-generation sequencingPregnancy

Identifiers

PMID40200155
PMCPMC11980175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.