ArticleNature metabolism2025
TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium efflux.
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Article in Nature metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Protein S-nitrosylation in the heart: Mechanisms, physiological roles, and pathological remodeling.Redox biology · 2026Review
- Asymmetric distribution of mitochondrial CaExperimental & molecular medicine · 2026Article
- The Role of Metal Ions in Mitochondria: From Energy Metabolism to Cell Destiny.Biological trace element research · 2026Review
- Molecular mechanisms of mitochondrial CaNature communications · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- Nrf2 modulates cytosolic and mitochondrial calcium signal.Redox biology · 2026Article
- Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.The EMBO journal · 2026Article
- The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026Review
- Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis.Precision clinical medicine · 2026Review
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- Reconstructing calcium conductance in MCUb illuminates its molecular design for tuning the mitochondrial calcium uniporter.Nature communications · 2026Article
- A Photothermal Transducer Regulates Transmembrane Calcium Flow for Synergistic Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- MICU proteins facilitate calcium-dependent mitochondrial metabolon formation to regulate cellular energetics independently of MCU.Nature metabolism · 2026Article
- Loss of TMEM65 in mice causes mitochondrial disease mediated by mitochondrial CaNature communications · 2026Article
- Chronic cold exposure induces plasticity of mitochondrial calcium uptake in beige and brown fat of UCP1-deficient mice.bioRxiv : the preprint server for biology · 2026Article
- Mitochondrial Calcium Signaling in Hepatocyte Health and Disease.Cold Spring Harbor perspectives in biology · 2026Review
- Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Reviews in cardiovascular medicine · 2026Review
- Molecular mechanisms of mitochondrial CabioRxiv : the preprint server for biology · 2026Article
- Genomic structural equation modeling reveals shared genetic structure of cardiac function and structure-function association studies of CLCNKA mutations.Scientific reports · 2026Article
- Mitochondrial CaBiomolecules · 2026Review
Corrections and comments
- Update of
Authors and funding
15 authors.
Joanne F GarbinciusAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-4334-6445
Oniel SalikAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Henry M CohenAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-2172-2008
Carmen Choya-FocesAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Adam S MangoldAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Angelina D MakhoulAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0007-6119-5779
Anna E SchmidtAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dima Y KhalilAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Joshua J DoolittleAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0009-0001-9379-1205
Anya S WilkinsonAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Emma K MurrayAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Michael P LazaropoulosAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Alycia N HildebrandAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Dhanendra TomarAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-3144-7257
John W ElrodAging + Cardiovascular Discovery Center, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. elrod@temple.edu.ORCID http://orcid.org/0000-0003-3925-2224
Funding
Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Douglas Tilley · 2017 to 2026
$21.0MTargeting Pathways Involved in Cardiac Injury for Novel Repair StrategiesP01HL147841 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2020 to 2024
$11.4MIntegrative Cardiovascular PathophysiologyT32HL091804 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2008 to 2024
$4.5MMolecular composition of the mitochondrial calcium uniporter and cardiac pathophysiologyR01HL142271 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI ELROD, JOHN WILLIAM, HAJNOCZKY, GYORGY · 2018 to 2021
$3.0MMitochondria and metabolism in neurodegenerationRF1NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2021 to 2021
$2.3MMetabolic pathways in cardiac physiology and heart failureR01HL172926 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI John William Elrod · 2025 to 2026
$1.5MMitochondria and metabolism in neurodegenerationR01NS121379 · NINDS · TEMPLE UNIV OF THE COMMONWEALTH · PI ELROD, JOHN WILLIAM · 2024 to 2025
$1.5MImpact of mitochondrial structure on cellular homeostasis and hepatic injuryR00DK120876 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI TOMAR, DHANENDRA · 2022 to 2024
$986kImpact of mitochondrial structure on cellular homeostasis and hepatic injuryK99DK120876 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI TOMAR, DHANENDRA · 2020 to 2021
$181kThe Role of MICU3 in Alzheimer's Disease PathogenesisF30AG082407 · NIA · TEMPLE UNIV OF THE COMMONWEALTH · PI Henry Cohen · 2023 to 2026
$178kMolecular modulation of the mitochondrial Na+/Ca2+ exchanger as a novel therapeutic target for heart failure.F32HL151146 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GARBINCIUS, JOANNE FRANCES · 2020 to 2021
$134kAmerican Heart Association (American Heart Association, Inc.) 20EIA35320226American Heart Association (American Heart Association, Inc.) 24CDA1268083NHLBI NIH HHS F32 HL151146NHLBI NIH HHS P01 HL134608NHLBI NIH HHS P01 HL147841NHLBI NIH HHS R01 HL142271NHLBI NIH HHS R01 HL172926NHLBI NIH HHS T32 HL091804NIA NIH HHS F30 AG082407NIDDK NIH HHS K99 DK120876NIDDK NIH HHS R00 DK120876NINDS NIH HHS R01 NS121379NINDS NIH HHS RF1 NS121379U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5F30AG082407U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5F30HL152564U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL143931U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) F32HL151146U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL134608U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) P01HL147841U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS121379
Abstract
The balance between mitochondrial calcium (
Indexed as
CalciumMembrane ProteinsMitochondriaMitochondrial ProteinsSodium-Calcium ExchangerAnimalsHumansMiceMice, Inbred C57BLCalciumMembrane ProteinsMitochondrial ProteinsSodium-Calcium Exchanger
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.