Evidence map›Paper›PMID 40200066›Full record

ArticleScientific reports2025

Tertiary butylhydroquinone regulates oxidative stress in spleen injury induced by gas explosion via the Nrf2/HO-1 signaling pathway.

Jing Ma, Junhe Zhang, Lingling Xi, Junxing Qu, Shuangping Ma, Sanqiao Yao, Jie Liu, Wenjie Ren

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jing MaThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China.
Junhe ZhangThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China. zjh@xxmu.edu.cn.
Lingling XiThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China.
Junxing QuThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China.
Shuangping MaThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China.
Sanqiao YaoSchool of Public Health, Xinxiang Medical University, Xinxiang, 453003, Henan, China.
Jie LiuInternational Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada.
Wenjie RenThe Third Affiliated Hospital of Xinxiang Medical University, No. 83 Hualan Road, Xinxiang, 453003, Henan, China. 171001@xxmu.edu.cn.

Funding

the Open Project Program of the Third Affiliated Hospital of Xinxiang Medical University KFKTYB202108
6 · The paper itself

Abstract

Gas explosion is a recurrent event in coal mining that cause severe spleen damage. This study aimed to investigate the role and mechanism of oxidative stress in gas explosion-induced spleen injury. 120 male Sprague-Dawley (SD) rats were randomly divided into a control group (NC), a gas explosion-induced spleen injury model group (Model), an Nrf2 inhibitor group (Model + ATRA), and an Nrf2 induction group (Model + TBHQ). After explosion, the rats of the inhibitor group and induction group were immediately given intraperitoneal injection of all-trans-retinoicacid (ATRA, 5 mg/kg) or tertiary butylhydro-quinone (TBHQ, 1 mg/kg) once. Then, the rats were anesthetized with blood taken from the abdominal aorta at 24 h, 72 h and 7 days. The results showed that gas explosion reduced the spleen index. The expression of oxidative stress-related genes and proteins Nrf2, HO-1, COX2 and GPX4 were increased significantly (P < 0.05) after gas explosion. Compared with the model group, TBHQ improved the spleen index, and reduced inflammation. Moreover, the expression of inflammatory factor IL-6 and ROS was decreased (P < 0.05), HMOX1 and the expression of oxidative stress-related genes and proteins were increased (P < 0.05), but the opposite results were observed in the inhibitor group. Taken together, we firstly found that TBHQ may regulate the degree of oxidative stress in spleen injury induced by gas explosion through the Nrf2/HO-1 signaling pathway.

Indexed as

Blast InjuriesExplosionsHydroquinonesNF-E2-Related Factor 2Oxidative StressSignal TransductionSpleenAnimalsHeme Oxygenase (Decyclizing)MaleRatsRats, Sprague-Dawley2-tert-butylhydroquinoneHeme Oxygenase (Decyclizing)Hmox1 protein, ratHydroquinonesNfe2l2 protein, ratNF-E2-Related Factor 2Gas explosionOxidative stressSpleen injuryTertiary butylhydroquinone (TBHQ)

Identifiers

PMID40200066
PMCPMC11978986

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.