Trial reportNature medicine2025
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial.
Trial report in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Cognitive Behavioral Therapy for Individuals With Low Literacy and Perinatal Depression: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Cost-effectiveness of a technology-assisted peer-delivered perinatal mental health intervention in Pakistan: an economic evaluation using trial evidence.BMJ global health · 2025Trial
- Bridging Gaps in Perinatal Mental Health: A Review of Peer and Non-specialist Supports for Racially, Ethnically and Culturally Diverse Communities in the U.S.Current psychiatry reports · 2026Review
- Advances in Perinatal Depression: A Focus on Screening and Treatment.Journal of clinical medicine · 2026Review
- Effectiveness of psychological interventions for reducing depressive symptoms among women experiencing perinatal depression: a systematic review.AJOG global reports · 2026Review
- Identification, Prevention, and Treatment of Perinatal Depression in Low- and Middle-Income Countries: A Narrative Review.Biological psychiatry · 2026Review
- Technology-assisted platform (TAP) for training and supervision of task-shared psychosocial interventions to ensure competency during scale-up in low-resource settings.Global mental health (Cambridge, England) · 2026Article
- Comparing standard and technology-assisted peer-delivered CBT for perinatal depression: A causal mediation study.Global mental health (Cambridge, England) · 2026Article
- Thinking local, thinking healthy: Cultural and contextual adaptation of the Thinking Healthy Programme in Nepal.Global mental health (Cambridge, England) · 2026Article
- The pieces are already built: converging India's national assets to close the mental health treatment gap.Frontiers in digital health · 2026Article
- Peers as humans in the loop in digital mental health.Nature medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Perinatal depression affects one in four women in low- and middle-income countries. The World Health Organization's Thinking Healthy Programme (WHO-THP) is an established 'task-shared' cognitive-behavioral therapy intervention for perinatal depression. However, efforts to scale up are hampered by overburdened health systems struggling to maintain quality and fidelity. Here, to overcome these challenges, we coproduced with end users a technology-assisted digital version of the THP delivered by lived-experience peers (technology-assisted peer-delivered THP (THP-TAP)). We aimed to evaluate the effectiveness of THP-TAP compared to the established WHO-THP. A single-blind cluster-randomized controlled noninferiority trial was conducted in rural Rawalpindi, Pakistan, with 70 village clusters randomly distributed to the two interventions. From June 2022 to May 2023, we recruited 980 women with perinatal depression registered with primary healthcare centers. The primary outcome was remission from the depressive episode at 3 months postnatal. On assessment of 846/980 (86.3%) participants at 3 months postnatal, the difference in the remission rate was 8.91% with the lower boundary of the one-sided 97.5% confidence interval being 4.25%, larger than the prespecified -10% noninferiority margin (P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.