Evidence map›Paper›PMID 40199927›Full record

ArticleScientific reports2025

Impact of anti-VZV IgG levels on Parkinson's disease risk and progression: a Mendelian randomization analysis.

Jinxing Sun, Xiangchen Li, Shengmei Ma, Haopeng Lin, Zhenke Li, Junheng Jia, Yasaman Alizadeh, Qianqian Wu, Ying Hou, Hong Wang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Herpes zoster vaccination and cognitive disorders in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jinxing Sun *Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Xiangchen Li *Department of Computer Science, The University of Manchester, Manchester, UK.
Shengmei MaDepartment of Radiology, Qilu Hospital of Shandong University, Jinan, China.
Haopeng LinDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Zhenke LiDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Junheng JiaDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Yasaman AlizadehDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Qianqian WuDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Ying HouDepartment of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Hong WangDepartment of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
Qi WangDepartment of Gerontology, Shandong Provincial Qianfoshan Hospital, Jinan, China.
Guangjian ZhangDepartment of Neurology, Weifang People's Hospital, Weifang, China.
Xingang LiDepartment of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China.
Weiguo Li *Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China. leeweiguo777@163.com.
Chao Zhang *Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Jinan, China. chao_zhang@sdu.edu.cn.

Funding

2022 Industrial Technology Basic Public Service Platform Project 2022-189-181Key R&D Program of Shandong Province 2022ZLGX03National Natural Science Foundation of China 81702469Natural Science Foundation of Shandong Province ZR2023MH321
6 · The paper itself

Abstract

Research suggests a potential link between varicella zoster virus (VZV) and Parkinson's disease (PD), but the causal relationship between anti-VZV IgG levels and PD is not well understood. Using two-sample Mendelian Randomization (MR), we assessed the causal impact of anti-VZV IgG levels on PD risk and progression. Our study found a significant association between higher anti-VZV IgG levels and an increased risk of PD. For PD progression, higher anti-VZV IgG levels were linked to a greater risk of constipation, insomnia, and Restless Legs. These findings remained consistent after sensitivity analyses. In conclusion, our study suggests that elevated anti-VZV IgG levels may contribute to an increased risk and progression of PD, supporting a potential causal link that warrants further mechanistic investigation.

Indexed as

Antibodies, ViralHerpesvirus 3, HumanImmunoglobulin GParkinson DiseaseDisease ProgressionHumansMendelian Randomization AnalysisRisk FactorsAntibodies, ViralImmunoglobulin GAnti-VZV IgG levelsMendelian randomizationParkinson’s diseaseVZV

Identifiers

PMID40199927
PMCPMC11978792

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.