Trial reportNature communications2025
Daytime eating during simulated night work mitigates changes in cardiovascular risk factors: secondary analyses of a randomized controlled trial.
Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02291952 (Development of Countermeasures Against Adverse Metabolic Effects of Shift Work), which is not on this map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Countermeasures Against Adverse Metabolic Effects of Shift Work
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review of Nutrition Interventions for Shift Workers, With Subgroup Analysis of First Responder Populations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Pooled it
- Long-term night shift work and cardiometabolic health in healthcare workers: a review of mechanisms and precision intervention strategies.Frontiers in public health · 2026Pooled it
- Pooled it
- Gut microbiota-mediated modulation of circadian rhythms: Physiological and molecular impacts of dietary composition and feeding time.Journal of food and drug analysis · 2026Review
- Dietary Behavior, Physical Activity, and 24-Hour Rhythm Coherence: A Digital Phenotyping Perspective on Vascular and Glycemic Health.Nutrients · 2026Review
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Investigating the Risk of Obesity in European Night Shift Workers: A Study Protocol for Cross-Sectional and Mechanistic Studies in the SHIFT2HEALTH Project.Obesity facts · 2026Article
- Night shift work, dietary patterns, and coronary heart disease.European journal of epidemiology · 2026Article
- Sex- and Ethnic Differences in the Cross-sectional Association Between Sleep Regularity and Obesity Among US Adults, NHANES 2011-2014.Journal of biological rhythms · 2026Article
- Chronic Night Shift Is More Detrimental Than Chronic Light at Night on Circadian Rhythmicity and Metabolic Health in a Female Diurnal Rodent.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Deep learning-based physiological risk stratification in night-shift hospital workers.Scientific reports · 2026Article
- Article
- Menstrual cycle and prior sleep shape women's responses to savory snacks during a mock night shift.Sleep · 2026Article
- Factor Structure and Measurement Invariance Across Gender of the Eating Disorder Examination Questionnaire-Short Form in Italian Workers.European journal of investigation in health, psychology and education · 2026Article
- Linking dynamic cerebral autoregulation and inhibitory executive function: Role of modifiable behaviours.Experimental physiology · 2026Review
- Nutritional adaptation to circadian misalignment: implications for musculoskeletal health in modern lifestyles.Frontiers in nutrition · 2026Review
- When hunger and thirst part ways: a longitudinal comparison of men and women across the Ramadan fasting-recovery cycle, with non-fasting controls.Frontiers in nutrition · 2026Article
- Factors influencing heart rate variability in nurses following night shifts: a prospective observational clinical study.BMC nursing · 2025Article
- Circadian nutrition and obesity: timing as a nutritional strategy.Journal of health, population, and nutrition · 2025Review
- Violence in Healthcare Workers Is Associated with Disordered Eating.International journal of environmental research and public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Effective countermeasures against the adverse cardiovascular effects of circadian misalignment, such as effects experienced due to night work or jet lag, remain to be established in humans. Here, we aim to test whether eating only during daytime can mitigate such adverse effects vs. eating during the night and day (typical for night shift workers) under simulated night work (secondary analysis of NCT02291952). This single-blind, parallel-arm trial randomized 20 healthy participants (non-shift workers) to simulated night work with meals consumed during night and day (Nighttime Meal Control Group) or only during daytime (Daytime Meal Intervention Group). The primary outcomes were pNN50 (percentage consecutive heartbeat intervals >50 ms), RMSSD (root mean square of successive heartbeat differences), and LF/HF (low/high cardiac frequency). The secondary outcome was blood concentrations of prothrombotic factor plasminogen activator inhibitor-1 (PAI-1). These measures were assessed under Constant Routine conditions, before (baseline) and after (postmisalignment) simulated night work. The meal timing intervention significantly modified the impact of simulated night work on cardiac vagal modulation and PAI-1 (pFDR = 0.001). In the Control Group, the postmisalignment Constant Routine showed a decrease in pNN50 by 25.7% (pFDR = 0.008) and RMMSD by 14.3% (pFDR = 0.02), and an increase in LF/HF by 5.5% (pFDR = 0.04) and PAI-1 by 23.9% (pFDR = 0.04), vs. the baseline Constant Routine. In the Intervention Group, there were no significant changes in these outcomes. For exploratory outcomes, the intervention significantly modified the impact of simulated night work on blood pressure (P < 0.05), with no significant change in the Control Group, and a significant reduction by 6-8% (P < 0.01) in the Intervention Group; without significant effects for heart rate or cortisol. These findings indicate that daytime eating, despite mistimed sleep, may mitigate changes in cardiovascular risk factors and offer translational evidence for developing a behavioral strategy to help minimize the adverse changes in cardiovascular risk factors in individuals exposed to circadian misalignment, such as shift workers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.