Evidence map›Paper›PMID 40199829›Full record

SynthesisActa neurologica Belgica2025

Statins and the risk of dementia: a meta-analysis.

Xue Li, Yuzhen Liu, Tiantian Song, Xiaoxuan Wu, Ying Xing

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xue LiDepartment of Neurology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, China.
Yuzhen LiuDepartment of Neurology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, China.
Tiantian SongDepartment of Neurology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, China.
Xiaoxuan WuDepartment of Neurology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, China.
Ying XingDepartment of Neurology, China-Japan Union Hospital of Jilin University, Jilin University, Changchun, 130033, China. xingying@jlu.edu.cn.ORCID http://orcid.org/0000-0001-9800-8569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clarify the relationship between the use of statins and the risk of dementia, and further guide the clinical application of statins. This paper uses computer search Chinese and foreign language databases Pubmed, Medline, Cochrane, Embase, Web of Science, Weipu, CBM, Wanfang, CNKI, etc., to include the literature that meets the standards from the establishment of the library to December 2020, and uses Revman 5.1 software and Stata15.0 software for meta-analysis. Of the 34 included observational studies, stratified subgroup analyses were performed based on the type of clinical trial, sex of participants, presence or absence of apolipoprotein E-4 (ApoEε4) allele, and duration of use. The conclusions showed that (1) the use of statins can significantly reduce the risk of dementia; (2) There is no significant sex difference in reducing the risk of dementia; (3) Continuous use of statins for ≥ 1 year can significantly reduce the risk of dementia compared with the time of taking the drug for < 1 year; (4) Compared with subjects with negative ApoEε4 allele, the use of statins has a more significant effect on reducing the risk of dementia in subjects carrying the ApoEε4 allele.

Indexed as

DementiaHydroxymethylglutaryl-CoA Reductase InhibitorsApolipoprotein E4HumansRisk FactorsApolipoprotein E4Hydroxymethylglutaryl-CoA Reductase InhibitorsDementiaEffectionMeta analysisStatins

Identifiers

PMID40199829

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.