Evidence map›Paper›PMID 40199586›Full record

ArticleeNeuro2025

New Mouse Lines That Drive Tetracycline-Controlled Gene Expression in a Small Subset of Spinal Cord Dorsal Horn Neurons.

Eric Fyrberg, Heather Learnard, Soojin Lee, Yong-Woo Jun, Fen-Biao Gao

Abstract read
In one paragraph

Article in eNeuro, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric FyrbergRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Heather LearnardDepartment of Neurology, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Soojin LeeRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605.
Yong-Woo JunRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605 Yong-Woo.Jun@umassmed.edu fen-biao.gao@umassmed.edu.
Fen-Biao GaoRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts 01605 Yong-Woo.Jun@umassmed.edu fen-biao.gao@umassmed.edu.

Funding

Investigating Pathogenic Mechanisms of Frontotemporal Dementia Caused by Mutations in CHMP2B and TBK1R37NS057553 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAO, FEN-BIAO · 2018 to 2024
$4.3M
Understanding Frontotemporal Dementia Using Drosophila and iPSC ModelsR01NS101986 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Fen-Biao Gao · 2017 to 2026
$3.6M
Synaptopathy and Pathogenesis in Frontotemporal Dementia: Role of CYLDRF1AG082478 · NIA · UPSTATE MEDICAL UNIVERSITY · PI GAO, FEN-BIAO, YAO, WEI-DONG · 2023 to 2023
$2.4M
NIA NIH HHS RF1 AG082478NINDS NIH HHS R01 NS101986NINDS NIH HHS R37 NS057553
6 · The paper itself

Abstract

Mouse lines with tetracycline-controlled gene expression in specific neuronal populations provide valuable tools for studying their development, function, connectivity, and pathology in vivo. Our initial goal was to generate a mouse model that could express amyotrophic lateral sclerosis-associated genes specifically in spinal cord motor neurons under the control of the

Indexed as

Gene ExpressionPosterior Horn CellsTetracyclineAmyotrophic Lateral SclerosisAnimalsDisease Models, AnimalHomeodomain ProteinsMiceMice, Inbred C57BLMice, TransgenicPromoter Regions, GeneticSpinal CordTranscription FactorsHb9 protein, mouseHomeodomain ProteinsTetracyclineTranscription FactorsHB9interneuronsmotor neuronspromoterspinal cordtetracycline

Identifiers

PMID40199586
PMCPMC12014207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.