Evidence map›Paper›PMID 40199581›Full record

ArticleJournal of neurointerventional surgery2026

The RED 43 catheter for aspiration thrombectomy of distal medium vessel occlusions (DMVOs): a multicenter experience.

Nitin Goyal, Nicolas K Khattar, Jeremy Peterson, Reza Dashti, Jason J Sims, Marlene Baumeister, Ari Williams, Iheanyi Amadi, Koji Ebersole, Dawn Madigan and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of neurointerventional surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nitin GoyalSemmes-Murphey Neurologic and Spine Institute, Memphis, Tennessee, USA ngoyal@semmes-murphey.com.
Nicolas K KhattarSemmes-Murphey Neurologic and Spine Institute, Memphis, Tennessee, USA.ORCID http://orcid.org/0000-0002-5077-9804
Jeremy PetersonNeurosurgery, University of Kansas, Kansas City, Kansas, USA.
Reza DashtiNeurosurgery, Stony Brook University, Stony Brook, New York, USA.
Jason J SimsThe University of Tennessee Health Sciences Center, Memphis, TN, USA.ORCID http://orcid.org/0009-0005-3393-0356
Marlene BaumeisterNeurosurgery, Stony Brook University, Stony Brook, New York, USA.
Ari WilliamsNeurosurgery, University of Kansas, Kansas City, Kansas, USA.
Iheanyi AmadiNeurosurgery, University of Kansas, Kansas City, Kansas, USA.
Koji EbersoleNeurosurgery, University of Kansas, Kansas City, Kansas, USA.
Dawn MadiganStony Brook University Health Sciences Center School of Medicine, Stony Brook, New York, USA.
Dina SymondsStony Brook University Health Sciences Center School of Medicine, Stony Brook, New York, USA.
Melissa GottschlichRadiology Imaging Associates, Englewood, Colorado, USA.ORCID http://orcid.org/0000-0002-2533-1194
Violiza Inoa-AcostaSemmes-Murphey Neurologic and Spine Institute, Memphis, Tennessee, USA.
Donald FreiInterventional Neuroradiology, Radiology Imaging Associates, Englewood, Colorado, USA.ORCID http://orcid.org/0000-0002-7811-5030
David FiorellaNeurosurgery, Stony Brook University, Stony Brook, New York, USA.ORCID http://orcid.org/0000-0002-2677-8780

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies support the effectiveness of mechanical thrombectomy (MT) for distal medium vessel occlusions (DMVOs). The RED 43 catheter has been introduced as a primary catheter for distal aspiration in acute ischemic stroke. In this multicenter study, we share our experience of using the RED 43 catheter for MT in DMVOs.

methodsWe identified consecutive patients with DMVOs who underwent primary aspiration thrombectomy using the RED 43 catheter at four high-volume stroke centers. We collected baseline clinical data, angiographic and clinical outcomes, and procedural complications. We divided the patients into two groups: those with primary DMVOs included patients who presented with more distal occlusions requiring mechanical thrombectomy; and those with secondary DMVOs being patients presenting with large vessel occlusion that later developed a DMVO. Primary outcomes included the rate of first pass effect, (modified treatment in cerebral infarction (mTICI) 2c or 3 on the first pass) and successful recanalization (mTICI≥2b at end of procedure). Secondary outcomes included good functional outcomes (modified Rankin Scale (mRS) 0-2 at 3 months), symptomatic intracerebral hemorrhage (sICH), asymptomatic intracerebral hemorrhage (aICH), subarachnoid hemorrhage (SAH), and in-hospital mortality.

resultsWe identified 102 consecutive DMVO cases undergoing thrombectomy with the RED 43 catheter. The mean age was 70 years, and the median National Institutes of Health Stroke Scale (NIHSS) score was 9. The first pass effect (FPE) rate was 57% (primary) and 61% (secondary). Successful recanalization occurred in 83% (primary) and 87% (secondary). Good functional outcome was observed in 57% of patients. sICH occurred in one patient, and two patients died during hospitalization. We observed aICH in five (4.9%) patients and SAH in seven (6.9%) patients.

conclusionThe RED 43 catheter is safe and effective for aspiration thrombectomy in primary and secondary DMVOs, with high recanalization rates and a favorable safety profile.

Indexed as

CathetersIschemic StrokeThrombectomyAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeCatheterEmbolicNavigationStrokeThrombectomy

Identifiers

PMID40199581
PMCPMC13217124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.