Evidence map›Paper›PMID 40199386›Full record

ArticleContemporary clinical trials2025

System Interventions to Achieve Early and Equitable Kidney Transplants (STEPS): Protocol for STEPS, a randomized comparative effectiveness clinical trial.

L Ebony Boulware, Patti L Ephraim, Tariq Shafi, Jamie A Green, Teri Browne, Tara S Strigo, Sarah Peskoe, Jonathan Wilson, Yuliya Lokhnygina, Aviel Alkon and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05014256 (System Interventions to Achieve Early and Equitable Transplants), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05014256 nacompletednot on this map

System Interventions to Achieve Early and Equitable Transplants (STEPS) Study

TypeinterventionalSponsorWake Forest University Health SciencesRan2022 to 2025Enrolled1,168ConditionsChronic Kidney DiseasesArmsSTEPS Health System Outreach intervention
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

L Ebony BoulwareWake Forest University School of Medicine, 525 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: lboulwar@wakehealth.edu.
Patti L EphraimFeinstein Institutes for Medical Research, Northwell Health, 350 Community Dr, Manhasset, NY 11030, USA. Electronic address: pephraim@northwell.edu.
Tariq ShafiUniversity of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA. Electronic address: tariq.shafi@bswhealth.org.
Jamie A GreenGeisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA. Electronic address: jgreen1@geisinger.edu.
Teri BrowneUniversity of South Carolina College of Social Work, 1705 College St, Columbia, SC 29208, USA. Electronic address: brownetm@mailbox.sc.edu.
Tara S StrigoWake Forest University School of Medicine, 525 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: tsmithst@wakehealth.edu.
Sarah PeskoeDuke University, 2080 Duke University Rd, Durham, NC 27708, USA. Electronic address: sarah.peskoe@duke.edu.
Jonathan WilsonDuke University, 2080 Duke University Rd, Durham, NC 27708, USA. Electronic address: jonathan.a.wilson@duke.edu.
Yuliya LokhnyginaDuke University, 2080 Duke University Rd, Durham, NC 27708, USA. Electronic address: yuliya.lokhnygina@duke.edu.
Aviel AlkonDuke University, 2080 Duke University Rd, Durham, NC 27708, USA. Electronic address: aviel.alkon@duke.edu.
George L JacksonUniversity of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA; Durham Veterans Affairs Health Care System, Implementation and Improvement Science Lab, Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), HSR&D (152), Suite 600, 411 West Chapel Hill Street, Durham, NC 27701, USA. Electronic address: george.jackson@utsouthwestern.edu.
Matthew J EllisDuke University Health System, 2200 W Main St, Durham, NC 27705, USA. Electronic address: matthew.ellis@duke.edu.
Debra SudanDuke University Health System, 2200 W Main St, Durham, NC 27705, USA. Electronic address: debra.sudan@duke.edu.
Blake CameronDuke University Health System, 2200 W Main St, Durham, NC 27705, USA. Electronic address: blake.cameron@duke.edu.
Pradeep K VaitlaUniversity of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216, USA. Electronic address: pvaitla@umc.edu.
Ashley CabacunganDuke University, 2080 Duke University Rd, Durham, NC 27708, USA. Electronic address: cabacungana14@gmail.com.
Lauren BrubakerGeisinger Health System, 100 N Academy Ave, Danville, PA 17822, USA. Electronic address: labrubaker@geisinger.edu.
Emily L ObermillerWake Forest University School of Medicine, 525 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: eobermil@wakehealth.edu.
Clarissa J DiamantidisWake Forest University School of Medicine, 525 Vine Street, Winston-Salem, NC 27101, USA. Electronic address: cdiamant@wakehealth.edu.

Funding

Health system outreach to eliminate disparities in living kidney transplants (System Interventions to Achieve Early and Equitable Transplants (STEPS) StudyU01DK127918 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOULWARE, LEIGH E · 2020 to 2020
$5.6M
NIDDK NIH HHS U01 DK127918
6 · The paper itself

Abstract

The System Interventions to Achieve Early and Equitable Kidney Transplants Study (STEPS) is an ongoing pragmatic clinical trial investigating the effectiveness of an equitable and patient-centered approach to kidney care on equitable access to early kidney transplants for individuals with chronic kidney disease not on dialysis. The STEPS intervention combines active electronic health record surveillance to equitably identify all potentially eligible kidney transplant candidates in three health systems ('STEPS Surveillance') with a 'STEPS Outreach Program' (comprised of equity-conscious patient-centered transplant social worker and transplant coordinator outreach and navigation activities). Identified eligible participants are randomly assigned to receive either (a) Augmented Usual Kidney Care (routine care plus electronic surveillance and best practice alerts), or (b) the STEPS Health System Surveillance and Outreach Intervention plus Augmented Usual Kidney Care to improve access to kidney transplants overall as well as among Black and rural residing individuals. STEPS recruited all planned 1168 participants from March 2022 to March 2024. Outcomes will quantify differences between the study arms in progress toward and completion of kidney transplant evaluations, assessed via medical records, and patient-reported outcomes. Registration of clinical trials This study is registered at ClinicalTrials.gov under the identifier NCT05014256.

Indexed as

Healthcare DisparitiesHealth EquityHealth Services AccessibilityKidney TransplantationRenal Insufficiency, ChronicBlack or African AmericanComparative Effectiveness ResearchElectronic Health RecordsHumansPatient-Centered CarePragmatic Clinical Trials as TopicRandomized Controlled Trials as Topic

Identifiers

PMID40199386
PMCPMC12434597

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.