SynthesisJournal of the American Academy of Orthopaedic Surgeons. Global research & reviews2025
A Systematic Review and Meta-Analysis of Periprosthetic Joint Infection Rates in Morbidly Obese Patients Undergoing Total Hip Arthroplasty.
Synthesis in Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No Mid-Term Benefits of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists Following Total Joint Arthroplasty: A Systematic Review.The Journal of bone and joint surgery. American volume · 2026Pooled it
- Review
- The Growing Impact of Severe Obesity on 90-Day Outcomes After Elective Primary Total Hip Arthroplasty: A National Propensity-Matched Study.Arthroplasty today · 2026Article
- Geriatric Total Hip Arthroplasty: Fixation Strategies, Approaches and Outcomes.Journal of orthopaedics and sports medicine · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPeriprosthetic joint infection (PJI) is a severe complication associated with higher rates in obese individuals after total hip arthroplasty (THA). Hard cutoffs for body mass index (BMI) levels may lead to restricted access to care; however, a certain level of obesity may warrant these restrictions for patient safety. The purpose of this study was to perform a systematic review and meta-analysis of articles comparing PJI rates in morbidly versus nonmorbidly obese patients undergoing primary THA.
methodsA systematic search of PubMed, EMBASE, Cochrane, and Google Scholar databases was conducted following Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Original studies comparing PJI rates in morbidly obese (BMI ≥40 kg/m2) and nonobese (BMI <40 kg/m2) THA patients were included. Data extraction, bias assessment, and quantitative synthesis were done.
resultsAfter exclusion criteria, 10 studies comprising 46,080 THAs were included. Morbidly obese patients were found to have markedly higher rates of PJI compared with nonmorbidly obese patients (odds ratio = 4.332, 95% confidence interval [CI], 2.943 to 6.375, I2 = 0, P-value = 0.901). Analysis of cohorts stratified by BMI showed consistent trends; morbidly obese patients demonstrated markedly increased risk of blood transfusions, postoperative fractures, superficial infections, dislocations, readmission within 90 days, surgical complications, and revision surgery.
conclusionMorbidly obese patients demonstrate markedly increased risk of PJI and other complications after primary THA. This should be discussed with patients to safely provide the option of THA while minimizing restrictions on access to care.
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Registered trials
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