ArticleThe Journal of organic chemistry2025
Nickel-Catalyzed Deuteration of Primary, Secondary, and Tertiary Silanes: Scope and Mechanistic Insights.
Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Electrochemically deuterated silane synthesis with DScience advances · 2026Article
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Authors and funding
6 authors.
Funding
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Abstract
Deuterated silanes are crucial reagents for deuteration, with a diverse range of applications in materials science, pharmaceuticals, and isotopic labeling. While most methods for synthesizing deuterated silanes rely on stoichiometric environmentally harmful processes or noble metal catalysts, research into more sustainable alternatives has received relatively less attention. In this study, we introduce a catalyst based on a nickel PBP-pincer system (PBP = bis(phosphino)boryl), which effectively facilitates catalytic hydrogen/deuterium exchange for primary, secondary, and tertiary silanes, as well as tertiary siloxanes and certain boranes, utilizing a catalyst loading of 2 mol % at 25 °C. DFT calculations identify two reaction pathways that require overcoming similar energy barriers for the H/D exchange step: silane activation assisted by the PBP ligand (Δ
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Registered trials
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