ArticleThe Journal of clinical endocrinology and metabolism2025
Association Between Visit-to-Visit Glucose Variability and Brain Morphology and Cognitive Function in Type 2 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural and functional brain abnormal alteration in patients with type 2 diabetes mellitus: A coordinate-based meta-analysis.Translational psychiatry · 2025Pooled it
- Association Between Visit-to-Visit Glucose Variability and Brain Morphology and Cognitive Function in Type 2 Diabetes.The Journal of clinical endocrinology and metabolism · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
objectiveTo investigate the effect of varying visit-to-visit glucose variability (GV) on brain morphometry and cognitive performance in patients with type 2 diabetes mellitus (T2DM).
methodsThis was a retrospective cohort study in which we recruited 426 participants (173 T2DM patients and 253 healthy controls) who underwent cognitive assessment and structural magnetic resonance imaging. In patients with T2DM, visit-to-visit GV was calculated using the SD of glycated hemoglobin (HbA1c) during the follow-up period. Multiple linear regression models were used to analyze the associations between different levels of GV and brain morphometry as well as cognitive function after adjusting for mean HbA1c levels and other traditional risk factors.
resultsHigher GV is associated with poorer global cognitive performance and executive function. After full multivariate adjustment, higher GV is linked to cortical thinning in the left superior parietal cortex, right postcentral gyrus, and insula, as well as a reduction in total gray matter volume. In contrast, no association was observed between GV and cortical volume or surface area.
conclusionOur findings indicate that higher visit-to-visit GV is associated with reduced cortical thickness, total gray matter volume atrophy, and poorer cognitive performance in patients with T2DM, and these associations are independent of mean HbA1c levels.
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