Evidence map›Paper›PMID 40198605›Full record

ArticlePLOS global public health2025

In danger: HIV vaccine research and development in Europe.

Roger Tatoud, Yves Lévy, Roger Le Grand, Jose Alcami, Giorgio Barbareschi, Christian Brander, Andrea Cara, Behazine Combadière, François Dabis, Sarah Fidler and 20 more

Abstract read
In one paragraph

Article in PLOS global public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Roger TatoudOrigena Consulting, Ferney Voltaire, France.ORCID https://orcid.org/0000-0002-3999-8264
Yves LévyVaccine Research Institute, Créteil, France.
Roger Le GrandDepartment of Infectious Diseases Models for Innovative Therapies, CEA, Fontenay aux Roses, France.ORCID https://orcid.org/0000-0002-4928-4484
Jose AlcamiFundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.ORCID https://orcid.org/0000-0003-0023-7377
Giorgio BarbareschiEuropean AIDS Treatment Group, Brussels, Belgium.
Christian BranderIRSICAIXA AIDS Research Institute, Barcelona, Spain.ORCID https://orcid.org/0000-0002-0548-5778
Andrea CaraIstituto Superiore di Sanità, Rome, Italy.ORCID https://orcid.org/0000-0003-4967-1895
Behazine CombadièreSanofi, Marcy-l'Étoile, France.
François DabisUniversity of Bordeaux, Bordeaux, France.ORCID https://orcid.org/0000-0002-1614-8857
Sarah FidlerDepartment of Infectious Disease, Imperial College London, London, United Kingdom.
Tomáš HankeThe Jenner Institute, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0002-6076-9546
Carolina HerreraCONRAD, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, United States of America.ORCID https://orcid.org/0000-0003-3701-752X
Gunilla B Karlsson HedestamDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-7255-9047
Hester KuipersIAVI, Amsterdam, The Netherlands.
Sheena McCormackMRC Clinical Trials Unit, University College London, London, United Kingdom.ORCID https://orcid.org/0000-0002-7829-1325
Christiane MoogUMR_S INSERM, Université de Strasbourg, Strasbourg, France.ORCID https://orcid.org/0000-0002-0916-156X
Giuseppe PantaleoDepartment of Medicine and Laboratory Medicine, University of Lausanne, Lausanne, Switzerland.
Laura RichertUniversity of Bordeaux, Bordeaux, France.ORCID https://orcid.org/0000-0002-7682-2225
Rogier W SandersAmsterdam University Medical Centers, Amsterdam, Netherlands.
Robin ShattockDepartment of Medicine, Imperial College London, London, United Kingdom.
Hendrik StreeckInstitute of Virology, Bonn, Germany.ORCID https://orcid.org/0000-0002-0335-6390
Rodolphe ThiebautUniversity of Bordeaux, Bordeaux, France.ORCID https://orcid.org/0000-0002-5235-3962
Alexandra TrkolaInstitute of Medical Virology, Zurich, Switzerland.
Klaus ÜeberlaVirology Institute, Erlangen, Germany.ORCID https://orcid.org/0000-0001-7822-3835
Marit J Van GillsDepartment of Medical Microbiology and Infection Prevention, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0003-3422-8161
Ralf WagnerInstitute of Medical Microbiology and Hygiene, Molecular Microbiology (Virology), Regensburg, Germany.ORCID https://orcid.org/0000-0002-2029-3846
Winfried WeissenhornInstitut de Biologie Structurale (IBS), Grenoble, France.ORCID https://orcid.org/0000-0001-5532-4959
Yazdan YazdanpanahANRS Emerging Infectious Diseases, Paris, France.
Gabriella ScarlattiViral Evolution and Transmission Group, IRCCS Ospedale San Raffaele, Milan, Italy.ORCID https://orcid.org/0000-0003-2316-2689
Jean Daniel LelièvreDepartment of Infectious Diseases & Clinical Immunology, Henri Mondor University Hospital, Créteil, France.ORCID https://orcid.org/0000-0002-8182-3628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly effective antiretroviral-based HIV prevention plays an important role in ending the global HIV/AIDS epidemic. However, the sustainable control of the epidemic is hampered by unequal access to prevention options, including HIV testing, alongside with drug resistance and ongoing barriers to accessing sustainable HIV treatment. Therefore, an HIV vaccine, combined with effective prevention and treatment, remains an absolute necessity to control the epidemic. Yet, the recent discontinuation of four major vaccine efficacy studies is raising concerns about the future of HIV vaccine research and development globally, and particularly in the European region where funding for vaccine research and development has shrinked. This viewpoint emphasises that supporting HIV vaccine research and development at the European level remains crucial: it is not only necessary to control the epidemic, but it promotes innovation, strengthens health security, epidemic preparedness, and health sovereignty while contributing to the economies of European nations.

Identifiers

PMID40198605
PMCPMC11977976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.