Evidence map›Paper›PMID 40198413›Full record

ArticleImmunologic research2025

Role of basophils and type 2 inflammation in bullous pemphigoid pathophysiology: a comparative study of blood and blister fluid.

Bintao Su, Quanhong Zhang, Xianyong Hu, Bo Xie, Chao Chen, Yan Zhao, Zhi Liu, Ling Ma, Jinbo Chen

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Bintao Su *Department of Clinical Laboratory, Wuhan No.1 Hospital, Wuhan, China.
Quanhong Zhang *Department of Dermatology, Wuhan No.1 Hospital, Wuhan, China.
Xianyong HuDepartment of Clinical Laboratory, Wuhan No.1 Hospital, Wuhan, China.
Bo XieDepartment of Clinical Laboratory, Wuhan No.1 Hospital, Wuhan, China.
Chao ChenDepartment of Clinical Laboratory, Wuhan No.1 Hospital, Wuhan, China.
Yan ZhaoDepartment of Dermatology, Wuhan No.1 Hospital, Wuhan, China.
Zhi LiuDepartment of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ling MaDepartment of Dermatology, Wuhan No.1 Hospital, Wuhan, China. maling555@126.com.
Jinbo ChenDepartment of Dermatology, Wuhan No.1 Hospital, Wuhan, China. chen999jb@163.com.

Funding

the Top talent project of Hubei Health Commission no grant IDWuhan Municipal Health Commission WX20B17
6 · The paper itself

Abstract

Bullous pemphigoid (BP) is an autoimmune disease characterized by blister formation and inflammatory cell infiltration. In addition to eosinophil and neutrophil infiltration, there are many other inflammatory cells and factors involved in the pathophysiology of BP. Elucidating the inflammation environment will help to the diagnosis and treatment of BP. We used flow cytometry and wright-stained smears to analyze immune cells, and cytometric bead array methods were used to analyze immune factors in matched blood and blister fluid. Besides abundant eosinophil and neutrophil accumulation, distinct basophil infiltration was detected in blister fluid of patients with BP. We also found significant CD4

Indexed as

BasophilsBlisterCD4-Positive T-LymphocytesInflammationPemphigoid, BullousAgedAged, 80 and overEosinophilsFemaleHumansInterleukin-4Lymphocyte ActivationMaleMiddle AgedNeutrophilsInterleukin-4BasophilsBlister fluidBullous pemphigoidCytokinesType 2 inflammation

Identifiers

PMID40198413

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.