Evidence map›Paper›PMID 40198408›Full record

ReviewTopics in current chemistry (Cham)2025

Exploring the Structural Versatility and Dynamic Behavior of Acyl/Aroyl Hydrazones: A Comprehensive Review.

Kulbir Kadyan, Rahul Singh, Jayant Sindhu, Parvin Kumar, Meena Devi, Sohan Lal, Ashwani Kumar, Devender Singh, Harish Kumar

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In one paragraph

Review in Topics in current chemistry (Cham), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kulbir Kadyan *Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
Rahul Singh *Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
Jayant SindhuDepartment of Chemistry, COBS&H, CCS Haryana Agricultural University, Hisar, 125004, India.
Parvin KumarDepartment of Chemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India. parvinchem@kuk.ac.in.
Meena DeviDepartment of Chemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
Sohan LalDepartment of Chemistry, Kurukshetra University, Kurukshetra, Haryana, 136119, India.
Ashwani KumarDepartment of Pharmaceutical Sciences, GJUS&T, Hisar, 125001, India.
Devender SinghDepartment of Chemistry, Maharshi Dayanand University, Rohtak, 124001, India.
Harish KumarDepartment of Chemistry, School of Basic Sciences, Central University Haryana, Mahendergarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acyl and aroyl hydrazones are hydrazine derivatives with unique structural variations and multiple applications in various disciplines, including medicinal chemistry, materials, and agrochemicals research. The presence of numerous reactive sites in acyl hydrazones established it as a privileged structure class in organic chemistry and, hence, serve as an important intermediate in the synthesis of pharmaceutically significant compounds. The intrinsic nature of the acylhydrazone group leads to various dynamic processes, including conformational, configurational, and tautomeric interconversions. Their dynamic behavior in organic frameworks is mainly attributed to hindered rotation around the imine C=N bond and -CONH- amide bond. It is crucial to comprehend the geometrical and conformational behavior of hydrazone derivatives in order to understand their structural attributes, reactivity, and interactions with other molecules. This review article provides an in-depth and up-to-date examination of the geometrical and conformational properties of acyl and aroyl hydrazones showcasing chronological progression of advancements in N-acyl/aroyl hydrazones (NAHs) over time spanning from 1955 to 2025. The insights gained from this analysis will be a helpful resource for researchers and chemists working on designing and developing new compounds with improved characteristics for various applications in chemistry and medicine.

Indexed as

HydrazonesMolecular ConformationMolecular StructureHydrazonesAcyl hydrazonesConformational isomerismGeometrical isomerism

Identifiers

PMID40198408

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.