Evidence map›Paper›PMID 40198395›Full record

ArticleVeterinary research communications2025

Fumonisin B1 induces oxidative stress, inflammation and necroptosis in IPEC-J2 cells.

Yinuo Zou, Xinyu Du, Xiaoyan Zheng, Sichao Mao, Xinyi Xu, Shuxia Zhang, Xingxiang Chen

Abstract read
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In one paragraph

Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Fumonisin BToxins · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yinuo ZouCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Xinyu DuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Xiaoyan ZhengCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Sichao MaoCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Xinyi XuCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Shuxia ZhangCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China.
Xingxiang ChenCollege of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China. cxx@njau.edu.cn.

Funding

National Natural Science Foundation of China 32273081
6 · The paper itself

Abstract

Fumonisin B1 (FB1), an important mycotoxin, poses a significant threat to public health and livestock production due to its widespread contamination. Furthermore, the gastrointestinal tract is particularly vulnerable to FB1 exposure given its frequent contamination of staple crops such as corn. Although necroptosis has been recognized as a critical mechanism underlying intestinal damage caused by certain environmental toxins, whether FB1 specifically triggers necroptosis in intestinal epithelial cells remains to be fully elucidated. In this study, the intestinal porcine epithelial cell line-J2 (IPEC-J2) was employed as an in vitro model to study the intestinal cells injury caused by FB1 and the underlying mechanisms. By measuring IPEC-J2 cell viability, intracellular reactive oxygen species, gene levels, and protein levels, it was found that FB1 dose-dependent induced IPFC-J2 cell injury, oxidative stress, and inflammation. Meanwhile, FB1 significantly increased the expression of necroptosis-related genes and proteins in IPEC-J2 cells, indicating that FB1 induced the occurrence of necroptosis. In summary, the results demonstrated FB1 can induce oxidative stress, inflammation and necroptosis in IPEC-J2 cells.

Indexed as

Epithelial CellsFumonisinsInflammationNecroptosisOxidative StressAnimalsCell LineCell SurvivalReactive Oxygen SpeciesSwinefumonisin B1FumonisinsReactive Oxygen SpeciesFumonisin B1InflammationIntestinal damageNecroptosisOxidative stress

Identifiers

PMID40198395

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.