Evidence map›Paper›PMID 40198358›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2025

Safety and dosimetry of [

Mark N Gaze, Daria Handkiewicz-Junak, Raquel Hladun, Theodore W Laetsch, Caryn Sorge, Richard Sparks, Simon Wan, Antony Ceraulo, Aneta Kluczewska-Galka, Cristina Gámez-Cenzano and 9 more

Erratum issued Registry-linked trialAbstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04711135 (A Multicenter Open-label Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With Somatostatin Receptor Positive Gastroenteropancreatic Neuroendocrine), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04711135 phase2active not recruitingnot on this map

A Multicenter Open-label Study to Evaluate Safety and Dosimetry of Lutathera in Adolescent Patients With Somatostatin Receptor Positive Gastroenteropancreatic Neuroendocrine (GEP-NET) Tumors, Pheochromocytoma and Paragangliomas (PPGL)

TypeinterventionalSponsorAdvanced Accelerator ApplicationsRan2022 to 2034Enrolled11ConditionsGastroenteropancreatic Neuroendocrine Tumors, Pheochromocytoma, ParagangliomaArmsLutetium [177Lu] oxodotreotide/dotatate
3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Fraction-dependent dose dynamics and clinical safety in high-risk neuroblastoma treated with [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  2. Trial
  3. Review
  4. Article
  5. Review
  6. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  7. Article
  8. Review
  9. Review
  10. Future of radiotheranostics.BMJ oncology · 2026
    Review
  11. Review
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Mark N GazeDepartment of Oncology, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-8344-7902
Daria Handkiewicz-JunakMaria Skłodowska-Curie Memorial National Research Institute of Oncology, Gliwice, Poland.ORCID 0000-0003-0802-2880
Raquel HladunHospital Vall d'Hebrón, Barcelona, Spain.
Theodore W LaetschDivision of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8497-3138
Caryn SorgeUniversity of Kentucky, Lexington, KY, USA.
Richard SparksCDE Dosimetry Services Inc, Knoxville, TN, USA.
Simon WanInstitute of Nuclear Medicine, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0001-6831-1129
Antony CerauloPaediatric Oncology Department, Centre Léon Bérard, Lyon, France.ORCID 0000-0002-4995-1494
Aneta Kluczewska-GalkaMaria Skłodowska-Curie Memorial National Research Institute of Oncology, Gliwice, Poland.
Cristina Gámez-CenzanoVall d'Hebrón University Hospital, Barcelona, Spain.ORCID 0000-0003-3562-8423
Lisa J StatesDepartment of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0003-0260-3975
Riham El KhouliUniversity of Kentucky, Lexington, KY, USA.
Paola AimoneNovartis Pharma AG, Basel, Switzerland.
Kevin PerraudAdvanced Accelerator Applications International S.A., Geneva, Switzerland.
Gabor KollarAdvanced Accelerator Applications S.A., Ruel-Malmaison, France.ORCID 0000-0003-1456-4520
Fariba KhanshanNovartis Pharmaceuticals Corp, East Hanover, NJ, USA.
Lars BlumensteinNovartis Biomedical Research, Basel, Switzerland.
Fazia BrouriAdvanced Accelerator Applications International S.A., Geneva, Switzerland.
Anne-Laure GiraudetLumen Nuclear Medicine Department, Centre Léon Bérard, Lyon, France. annelaure.giraudet@lyon.unicancer.fr.ORCID 0000-0002-5366-1254

Funding

Advanced Accelerator Applications, a Novartis Company Advanced Accelerator Applications, a Novartis Company
6 · The paper itself

Abstract

purposeNETTER-P, an open-label Phase II study, evaluated the safety and dosimetry of [

methodsPatients (12-17 years old) received four cycles of

resultsEleven patients (4 GEP-NET, 7 PPGL; median age 15 [range, 13-17] years) were enrolled and received ≥ 1 administration of

conclusionNo new safety signals attributable to

trial registrationClinicalTrials.gov, NCT04711135. Registered 15 January 2021.

Indexed as

Adrenal Gland NeoplasmsIntestinal NeoplasmsNeuroendocrine TumorsOctreotideOrganometallic CompoundsPancreatic NeoplasmsParagangliomaPheochromocytomaReceptors, SomatostatinSafetyStomach NeoplasmsAdolescentChildFemaleHumansMalelutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticalsReceptors, Somatostatin177Lu-DOTATATEDosimetryGastroenteropancreatic neuroendocrine tumours (GEP-NET)PaediatricPheochromocytoma and paragangliomas (PPGL)Radioligand therapy (RLT)

Identifiers

PMID40198358
PMCPMC12397115

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.