Evidence map›Paper›PMID 40198226›Full record

ReviewExperimental physiology2026

Spaceflight and sport science: Physiological monitoring and countermeasures for the astronaut-athlete on Mars exploration missions.

Luke DeVirgiliis, Nicholas J Goode, Kurt W McDowell, Kirk L English, Robert Novo, Virina Botros, Ginika Agwu, Jessica M Scott, Lori L Ploutz-Snyder

Abstract readReview
In one paragraph

Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luke DeVirgiliisDepartment of Exercise Science and Sport Science, East Tennessee State University, Johnson City, Tennessee, USA.
Nicholas J GoodeDepartment of Exercise Science and Sport Science, East Tennessee State University, Johnson City, Tennessee, USA.
Kurt W McDowellDepartment of Exercise Science and Sport Science, East Tennessee State University, Johnson City, Tennessee, USA.
Kirk L EnglishDepartment of Sport and Exercise Science, Milligan University, Milligan, Tennessee, USA.ORCID https://orcid.org/0000-0003-0423-339X
Robert NovoDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Virina BotrosAlbert Dorman Honors College, New Jersey Institute of Technology, Newark, New Jersey, USA.
Ginika AgwuDepartment of Medicine, CUNY School of Medicine, New York, New York, USA.
Jessica M ScottDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Lori L Ploutz-SnyderSchool of Kinesiology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-1369-7527

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Dose-response of aerobic training during total neoadjuvant therapy for locally advanced rectal cancerU01CA271287 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Jessica Scott · 2022 to 2026
$6.2M
Memorial Sloan Kettering Cancer Center Support P30 CA008748NCI NIH HHS 3U01CA271287-02S1NCI NIH HHS P30 CA008748NCI NIH HHS U01 CA271287
6 · The paper itself

Abstract

Long-duration spaceflight impacts essentially every system in the human body, resulting in multisystem deconditioning that might impair the health and performance of crewmembers, particularly on long-duration exploration missions to Mars. In this review, we apply the sport science model of athlete monitoring, testing and training to astronauts; tactical athletes, whose occupation includes physically demanding tasks. We discuss exploration-specific physiological monitoring modalities and provide a brief historical overview of physiological countermeasures to spaceflight. Finally, we suggest countermeasures to protect exploration crew health and performance, including targeted preflight and in-flight exercise training, in-flight exercise hardware and adjunct individualized nutrition and sleep considerations. Mars exploration missions will be exemplars of the astronaut-athlete paradigm. An integrated approach to physiological monitoring and countermeasures will maximize the likelihood of exploration mission success.

Indexed as

AstronautsSpace FlightSportsAthletesExerciseHumansMarsMonitoring, PhysiologicWeightlessnessWeightlessness Countermeasuresathlete monitoringcountermeasureshuman/environmental and exercise physiologyspaceflightsport science

Identifiers

PMID40198226
PMCPMC13395052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.