Evidence map›Paper›PMID 40198151›Full record

ArticleThe Analyst2025

Noninvasive and

Isamar Pastrana-Otero, Apurva R Godbole, Mary L Kraft

Abstract read
In one paragraph

Article in The Analyst, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Noninvasive andThe Analyst · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isamar Pastrana-OteroDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, USA. mlkraft@illinois.edu.ORCID http://orcid.org/0000-0003-3070-3623
Apurva R GodboleDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, USA. mlkraft@illinois.edu.
Mary L KraftDepartment of Chemical and Biomolecular Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, USA. mlkraft@illinois.edu.ORCID http://orcid.org/0000-0002-5879-7222

Funding

An objective noninvasive single-cell method to identify HSC differentiation stageR21HL132642 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KRAFT, MARY L · 2016 to 2017
$398k
NHLBI NIH HHS R21 HL132642
6 · The paper itself

Abstract

Microscale screening platforms that allow cells to interact in three dimensions (3D) with their microenviroment have been developed as a tool for identifying the extrinsic cues that might stimulate stem cells to replicate without differentiating within artificial cultures. Though these platforms reduce the number of valuable stem cells that must be used for screening, analyzing the fate decisions of cells in these platforms can be challenging. New noninvasive approaches for identifying the lineage-specific differentiation stages of cells while they are entrapped in the hydrogels used for these 3D cultures are especially needed. Here we used Raman spectra acquired from individual, living cells entrapped within a hydrogel matrix and multivariate analysis to identify cell phenotype noninvasively and

Indexed as

Cell DifferentiationHematopoietic Stem CellsHydrogelsAnimalsCell Culture Techniques, Three DimensionalCell LineCollagenDiscriminant AnalysisGelatinHumansMacrophagesMethacrylatesMicePhenotypeSpectrum Analysis, RamanCollagenGelatinHydrogelsMethacrylates

Identifiers

PMID40198151
PMCPMC11977708

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.