Evidence map›Paper›PMID 40198119›Full record

ArticleJournal of medicinal chemistry2025

Development of Squaramides as Allosteric Modulators of the CB

Thuy Nguyen, Ann M Decker, Daniel G Barrus, Chi Hyuck Song, Jianfeng Liu, Thomas F Gamage, Danni L Harris, Jun-Xu Li, Yanan Zhang

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. [Establishment and evaluation of rat and mouse models with addictive behaviors].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thuy NguyenCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.ORCID 0000-0002-3961-0901
Ann M DeckerCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.ORCID 0000-0003-1899-6558
Daniel G BarrusCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.
Chi Hyuck SongCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.ORCID 0009-0003-4423-4087
Jianfeng LiuDepartment of Pharmacology and Toxicology, University at Buffalo, the State University of New York, Buffalo, New York 14203, United States.
Thomas F GamageDepartment of Neuroscience and Physiology, Upstate Medical University, Syracuse, New York 13210, United States.ORCID 0000-0003-3528-9695
Danni L HarrisCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.
Jun-Xu LiDepartment of Pharmacology and Toxicology, University at Buffalo, the State University of New York, Buffalo, New York 14203, United States.ORCID 0000-0001-8103-7013
Yanan ZhangCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina 27713, United States.ORCID 0000-0001-7153-4358

Funding

Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
Allosteric Modulation of the CB1 ReceptorR01AA030509 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI Joyce Besheer, Yanan Zhang · 2023 to 2026
$2.5M
Allosteric Modulation of the CB1 ReceptorR01DA040693 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZHANG, YANAN · 2016 to 2020
$2.4M
In vitro and in vivo characterization of CB1 allosteric modulatorsK01DA045752 · NIDA · UPSTATE MEDICAL UNIVERSITY · PI GAMAGE, THOMAS F · 2018 to 2022
$807k
NIAAA NIH HHS R01 AA030509NIDA NIH HHS K01 DA045752NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA040693
6 · The paper itself

Abstract

Cannabinoid receptor type 1 (CB

Indexed as

AmidesCocaineReceptor, Cannabinoid, CB1Allosteric RegulationAnimalsBehavior, AnimalCocaine-Related DisordersHumansMaleModels, MolecularRatsRats, Sprague-DawleyStructure-Activity RelationshipAmidesCocaineReceptor, Cannabinoid, CB1

Identifiers

PMID40198119
PMCPMC12186189

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.