Trial reportDental press journal of orthodontics2025
Comparative evaluation of antimicrobial properties of silver nanoparticles and chlorhexidine mouthwashes on the colonization of microflora and oral health during orthodontic treatment: a double-blind randomized controlled trial.
Trial report in Dental press journal of orthodontics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFixed orthodontic appliances facilitate microbial adhesion and plaque accumulation. Although chlorhexidine has proven to be the most effective antiplaque and antigingivitis agent, it has several side effects.
objectiveThe present study aims to evaluate and compare the effectiveness of silver nanoparticles (SNP) and Chlorhexidine (CHX) mouthwash on reducing the microbial count and improving oral health during fixed orthodontic treatment. TRIAL
design4-arm parallel, placebo-controlled, double-blind randomized clinical trial with an allocation ratio of 1:1:1:1.
methodsMicrobial count of Streptococcus spp., Plaque Index, Gingival Index, Gingival Bleeding Index and Pocket Probing Depth were evaluated in 80 orthodontic patients at T0 (Pretreatment), T1 (four weeks after bonding) and T2 (four weeks after mouthwash prescription). Then patients were randomized into four groups: G1) NanOlife (containing SNP), G2) Chlorhex (containing 0.2% chlorhexidine), G3) Placebo, and G4) negative control (no mouthwash prescription) (n=20 each group). The effects of orthodontic treatment and mouthwashes were analyzed statistically.
resultsThe microbial count and all the four indices increased between T0 and T1 (P<0.05). They decreased below the baseline levels in Gp2, and back to baseline levels in Gp1 at T2 (P<0.05), except Gingival Bleeding index and Pocket Probing Depth. Both mouthwashes showed significantly improved therapeutic effects compared to placebo and negative control.
conclusionsAlthough SNP mouthwash was effective in the reduction of all the assessed parameters, it could not decrease them to the baseline levels, suggesting its limited efficacy. CHX mouthwash proved to be extremely effective by decreasing the microbial count, plaque index and gingival index below the baseline level.
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