ArticleEinstein (Sao Paulo, Brazil)2025
Impact of liver transplantation on the quality of life of a cohort of high-risk recipients.
Article in Einstein (Sao Paulo, Brazil), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundLiver transplantation significantly improves the health-related quality of life of patients with cirrhosis and high MELD scores. This study highlights rapid health-related quality of life gains after transplantation that were sustained during the one-year follow-up period, emphasizing the role of multidisciplinary care in achieving these outcomes.
objectiveTo assess the effects of liver transplantation on the health-related quality of life of patients with cirrhosis on the waiting list for transplantation.
methodsThis retrospective study analyzed HRQOL using the EQ-5D questionnaire before (T0), and 3 (T3), 6 (T6), and 12 (T12) months after, transplantation. The questionnaire comprised five health status scores, which were also combined into a single utility score. Changes in each dimension and in the utility score were examined.
resultsA total of 212 patients were included in the study, with a mean age of 54 (SD, 12) years, and a median Model for End-Stage Liver Disease score of 17 (Q1= 11; Q3= 24). The most frequent etiology was chronic alcoholism (26.9%). Improvements in EQ-5D utility scores were registered at all post-transplantation time points compared to the score at T0: an increase of 0.22 points (p<0.001) at T3, 0.27 (p<0.001) at T6, and 0.268 (p<0.001) at T12. Scores increased over time in all domains of the EQ-5D.
conclusionIn a large sample of high-risk transplant recipients, a significant improvement in HRQOL occurred three months after transplantation, and was sustained over the one-year follow-up period.
background■ Liver transplantation improves health-related quality of life in patients with cirrhosis and high MELD scores.
background■ Significant health-related quality of life improvements occur within three months of transplantation.
background■ Multidisciplinary care programs enhance post-iver transplantation physical and mental recovery.
background■ Sustained health-related quality of life gains highlight the long-term benefits of liver transplantation.
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