Evidence map›Paper›PMID 40197661›Full record

ArticleEuropean journal of neurology2025

Criminal Behavior in Early Onset Neurodegenerative Diseases.

Helmi Soppela, Mikko Aaltonen, Kalle Aho, Sami Heikkinen, Ave Kivisild, Adolfina Lehtonen, Laura Leppänen, Anna Mäki-Petäjä-Leinonen, Iina Rinnankoski, Laura Tervonen and 8 more

Abstract read
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In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Helmi SoppelaInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Mikko AaltonenLaw School, University of Eastern Finland, Joensuu, Finland.
Kalle AhoInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Sami HeikkinenInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-6976-2028
Ave KivisildInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Adolfina LehtonenResearch Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Laura LeppänenResearch Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Anna Mäki-Petäjä-LeinonenLaw School, University of Eastern Finland, Joensuu, Finland.
Iina RinnankoskiResearch Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Laura TervonenResearch Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Jari TiihonenDepartment of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.
Markku LähteenvuoDepartment of Forensic Psychiatry, University of Eastern Finland, Niuvanniemi Hospital, Kuopio, Finland.
Annakaisa HaapasaloA.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Anne M PortaankorvaDepartment of Neurology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Päivi HartikainenNeuro Center-Neurology, Kuopio University Hospital, Kuopio, Finland.
Kasper KatiskoInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.
Johanna KrügerResearch Unit of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland.
Eino SoljeInstitute of Clinical Medicine - Neurology, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-9940-9524

Funding

RocheSigrid Juséliuksen SäätiöSuomen AivosäätiöSuomen KulttuurirahastoSuomen Lääketieteen SäätiöThe State Research Fundingthe Strategic Neuroscience Funding of the University of Eastern FinlandWihuri Research Institute
6 · The paper itself

Abstract

introductionLiterature on criminal behavior preceding a neurodegenerative disease diagnosis is insufficient. Some studies suggest increased crime rates among patients with frontotemporal dementia (FTD).

methodsPatients with neurodegenerative diseases were gathered from Kuopio and Oulu University Hospitals and compared with nonselective general population data from Statistics Finland (N = 24,144). Clinical data were linked to the Finnish national register of police-reported crimes.

resultsIn total, 2424 participants with neurodegenerative diseases were included. Overall crime rates were notably higher among patients with FTD during the year before the diagnosis (9.4% for FTD, 6.3% for controls, p = 0.019). There was a significant drop in the criminal rates of FTD patients 3 years after the diagnosis (4.7% in the FTD, 12.3% in controls, p < 0.001). DISCUSSION: Criminal behavior is overrepresented in patients with FTD before the diagnosis. Criminal behavior manifesting in previously law-abiding individuals in late adulthood should be considered a potential early symptom of a neurodegenerative disease.

Indexed as

CrimeCriminal BehaviorFrontotemporal DementiaNeurodegenerative DiseasesAdultAgedAge of OnsetFemaleFinlandHumansMaleMiddle Agedbehavioral symptomscriminal behaviorcriminalitydementianeurodegeneration

Identifiers

PMID40197661
PMCPMC11977177

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.