Evidence map›Paper›PMID 40197611›Full record

ArticleJournal of neuropathology and experimental neurology2025

Molecular characterization of benign intracranial glioependymal and arachnoid cysts suggest heterogeneous mechanisms of action.

Stuart D Harper, Travis Perryman, Lindsey A Dudley, Ashna S Prabhu, Amani Carson, Alondra Delgadillo, Eliana S Oduro, Othneil Sparks, Aidan Gor, Shivani Baisiwala and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stuart D HarperDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-6105-8132
Travis PerrymanDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0009-0004-5247-8898
Lindsey A DudleyThe Intellectual and Developmental Disabilities Research Center and Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-3700-8220
Ashna S PrabhuDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0009-0008-3999-8396
Amani CarsonDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-8910-5153
Alondra DelgadilloDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Eliana S OduroDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0009-0002-7016-5540
Othneil SparksDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0002-4843-5009
Aidan GorDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Shivani BaisiwalaDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.ORCID 0000-0001-5252-9940
Ting ZhangDepartment of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Fausto RodriguezDepartment of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Kunal S PatelDepartment of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States.

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUSAN Y BOOKHEIMER · 2020 to 2026
$9.6M
Research Training in Cell and Molecular BiologyT32GM145388 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Jorge Torres · 2022 to 2026
$5.2M
JEDI JAM SeedMcKnight Neurobiology of Brain DisordersNCATS NIH HHS KL2 TR10082NCI NIH HHS P50 CA211015Neurosurgical Research and EducationNeurosurgical Research and Education Fund Young ClinicalNICHD NIH HHS P50 HD103557NIGMS NIH HHS T32 GM145388NIHNIH HHS T32GM145388Tower Cancer Center CareerTower Cancer Center Career Development
6 · The paper itself

Abstract

Benign-appearing intracranial cysts may become symptomatic due to mass effect and require surgical treatment. Mechanisms underlying cyst formation and growth remain poorly understood. This study identified 16 patients who underwent surgical treatment for benign intracranial cysts. Cyst wall pathologic samples (n = 8) were characterized as arachnoid or glioependymal cysts using H&E and immunofluorescence staining. Five samples (62.5%) were found to be glioependymal while three (37.5%) were arachnoid cysts. Cyst fluid examined in 4 cases resembled cerebrospinal fluid (CSF) and showed no significant differences in composition between pathological subtypes. Single-cell sequencing and RNA expression profile comparisons between glioependymal and arachnoid cysts revealed distinct cellular profiles. Analyses of the innermost cell layer (ependymal cells versus arachnoid cells) suggested differing mechanisms of pathogenesis. Glioependymal cysts harbored upregulated expression of sodium transporters and aquaporin channels, which suggests possible CSF-like fluid production whereas arachnoid cysts may be associated with mechanical fluid accumulation. Thus, intracranial cysts represent multiple unique pathologic entities with differing cell types and RNA expression profiles. Further study into mechanisms of glioependymal cyst formation may allow for targeted interventions to reduce fluid production and avoid surgery.

Indexed as

Arachnoid CystsAdultAgedFemaleHumansMaleMiddle Agedarachnoid cystbrain cystcerebrospinal fluidglioependymal cystneuroglial cystsingle-cell sequencing

Identifiers

PMID40197611
PMCPMC12192424

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.