Evidence map›Paper›PMID 40197550›Full record

ArticleArchives of public health = Archives belges de sante publique2025

Association of past obesity and BMI trajectories with cancer mortality: a prospective cohort study.

Huan Zhang, Junlong Zhao, Chenchen Wang, Jing Zhang, Xiaojing Zhu, Danxi Li, Zheyi Han, Lei Shang, Yongquan Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Huan Zhang *Air Force Medical Center, Department of Gastroenterology, Air Force Medical University, Beijing, China.
Junlong Zhao *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, 710032, China.
Chenchen WangDepartment of Critical Care Medicine, the 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, 730050, Gansu, China.
Jing ZhangState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China.
Xiaojing ZhuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China.
Danxi LiDepartment of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi, China.
Zheyi Han *Air Force Medical Center, Department of Gastroenterology, Air Force Medical University, Beijing, China. zheyihan_fmmu@163.com.
Lei Shang *Department of Health Statistics, School of Preventive Medicine, Air Force Medical University, Xi'an, China. shanglei@fmmu.edu.cn.
Yongquan Shi *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Air Force Medical University, Xi'an, 710032, China. shiyquan@fmmu.edu.cn.

Funding

National Natural Science Foundation of China 82170560
6 · The paper itself

Abstract

objectiveThis study aimed to assess the association of past obesity and past BMI trajectories with cancer mortality in National Health and Nutrition Examination Survey.

methodsPast obesity was identified based on past maximum body weight, and trajectories of past BMI change were determined by latent class trajectory modeling (LCTM). Cox regression was used to assess the association of past obesity and past BMI trajectories with cancer mortality.

resultsA total of 4,058 cancer patients participated in this study, of which 46.3% were past obesity, resulting in a significantly lower risk of cancer mortality compared to participants who were not past obesity (HR = 0.92, 95% CI: 0.92-0.93, P < 0.01). The LCTM identified five trajectories of past BMI, and compared with participants whose BMI remained in the normal range, the risk of death was 17% and 23% lower for participants in the "Long-term overweight" and "Long-term obesity" trajectory groups, respectively. In contrast, participants in the "Recent weight gain" and "Recent weight loss" trajectory groups had an increased risk of cancer death of 19% and 40%, respectively.

conclusionsThis study found that past obesity is consistent with the "obesity paradox." In furtherance, a moderately elevated and stable BMI might be associated with lower cancer mortality.

Indexed as

BMI trajectoryCancer mortalityNHANESObesity paradoxPast obesity

Identifiers

PMID40197550
PMCPMC11974108

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.