ArticleEuropean journal of preventive cardiology2025
Examining the Relationship Between Anthropometric and Body Composition measures with Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis.
Article in European journal of preventive cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Blood Levels of Angiotensinogen and Risk of Ischemic Stroke: The Multi-Ethnic Study of Atherosclerosis.Journal of the American Heart Association · 2026Observational
- The Obesity Paradox in Major Adverse Cardiovascular Events After PCI for Acute Coronary Syndrome: A Narrative Review.Journal of cardiovascular development and disease · 2026Review
- Correlation between the modified cardiometabolic index and the incidence of cardiovascular disease in a population with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.Scientific reports · 2026Article
- Association of CT-derived body composition with coronary plaque components and vascular inflammation.The journal of nutrition, health & aging · 2026Article
- Dynapenic Abdominal Obesity and the Risk of Stroke in Postmenopausal Women.International journal of women's health · 2026Article
- Dynapenic Abdominal Obesity and the Risk of Non-Neoplastic Digestive System Diseases in Postmenopausal Women: A Prospective Cohort Study.International journal of women's health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundObesity, traditionally measured using body mass index (BMI), is considered a significant risk factor for the development of cardiovascular disease. However, there have been mixed findings regarding the association between obesity and cardiovascular events in part due to the way it is measured. Major limitations exist with the use of BMI as it cannot assess body composition or fat distribution, and thus fails to account for the separate roles of muscle and fat mass.
objectiveTo examine the relationship between various measures of body composition including fat mass (FM), fat free mass (FFM), waist-to-height ratio, waist circumference, and BMI, and coronary heart disease (CHD) events, from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.
methodsMESA is a population-based cohort study of 6814 men and women, aged between 45 and 85 years, without clinically apparent CVD. FM and FFM at baseline (Exam 1) was estimated using multiplicative power equations formulated from bioelectrical impedance analysis (BIA) measurements. Multivariable Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for 10-year incident hard CHD events (non-fatal myocardial infarction (MI), resuscitated cardiac arrest, and death resulting from CHD) for FM/FFM, waist-to-height ratio, waist circumference, and BMI.
resultsHigher FM was associated with higher risk of hard CHD events, with a hazard ratio of 1.64 (1.09-2.48) per standard deviation (SD) unit increase (P-value 0.019). FFM was associated with a lower risk of CHD, with a hazard ratio of 0.24 (0.08-0.76) per SD unit increase of FFM (P-value 0.014). Waist-to-height ratio had a hazard ratio of 1.21 (1.08-1.35) (P-value 0.001) per SD unit increase in the ratio and was significantly associated with a higher risk of hard CHD events, as was waist circumference with a hazard ratio of 1.14 (1.03-1.28) (P-value 0.016) per SD unit increase. BMI had a hazard ratio of 1.08 (0.97-1.21) (P-value 0.158) and was not significantly associated with a 10-year risk of hard CHD events.
conclusionHigher FM, waist-to-height ratio, and waist circumference were associated with increased risk for hard CHD events while higher FFM was associated with decreased risk. This highlights the potential importance of lifestyle interventions to build muscle and minimize adiposity for the prevention of CVD and strengthens the call for the inclusion of alternative methodologies to define obesity and measure body composition in the clinical setting.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.