Evidence map›Paper›PMID 40197477›Full record

ArticleJournal of nanobiotechnology2025

Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis.

Ningning Yang, Rongrong Hua, Yingying Lai, Peijun Zhu, Jian Ding, Xianhui Ma, Gaoxiang Yu, Yiheng Xia, Chao Liang, Weiyang Gao and 5 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A mechanically compliant MnORSC advances · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
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  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ningning Yang *School of Pharmaceutical Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Rongrong Hua *School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Yingying Lai *Department of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, 325027, Zhejiang, China.
Peijun Zhu *School of Pharmaceutical Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.
Jian DingAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Xianhui MaDepartment of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, 325027, Zhejiang, China.
Gaoxiang YuDepartment of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, 325027, Zhejiang, China.
Yiheng XiaCixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Chao LiangCixi Biomedical Research Institute, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China.
Weiyang GaoDepartment of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, 325027, Zhejiang, China.
Zhouguang WangSchool of Pharmaceutical Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. wzhouguang@gmail.com.
Hongyu ZhangSchool of Pharmaceutical Sciences, Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China. st_hyz@126.com.
Liangliang YangAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China. liangliangyangLLL@126.com.
Kailiang ZhouDepartment of Orthopaedics, Zhejiang Provincial Key Laboratory of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou, 325027, Zhejiang, China. zhoukailiang@wmu.edu.cn.
Lu GeAffiliated Cixi Hospital, Wenzhou Medical University, Ningbo, 315300, Zhejiang, China. gelu100466@126.com.

Funding

National Natural Science Foundation of China 81801930National Natural Science Foundation of China 82072192National Natural Science Foundation of China 82372540Natural Science Foundation of Ningbo 2022J044Natural Science Foundation of Ningbo 2023J255Natural Science Foundation of Zhejiang Province LY23H060004Natural Science Foundation of Zhejiang Province LY24H110002Ningbo Major Science and Technology Research Project 2022Z146Zhejiang Provincial Medical and Health Science Foundation of China 2024KY155, 2023RC198
6 · The paper itself

Abstract

In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving flap viability include angiogenesis promotion, oxidative stress inhibition, and cell death prevention. Recently, two-dimensional ultrathin Ti

Indexed as

NanomedicineNanostructuresPyroptosisReactive Oxygen SpeciesSurgical FlapsTitaniumAnimalsEndothelial CellsHumansMaleMiceNecrosisNeovascularization, PhysiologicNitritesOxidative StressSignal TransductionMXeneNitritesReactive Oxygen SpeciesTitaniumTransition ElementsAngiogenesisIschaemic flapMXeneOxidative stressPyroptosis

Identifiers

PMID40197477
PMCPMC11978011

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.