Evidence map›Paper›PMID 40197396›Full record

ArticleeLife2025

Sex-dependent gastrointestinal colonization resistance to MRSA is microbiota and Th17 dependent.

Alannah Lejeune, Chunyi Zhou, Defne Ercelen, Gregory Putzel, Xiaomin Yao, Alyson R Guy, Miranda Pawline, Magdalena Podkowik, Alejandro Pironti, Victor J Torres and 2 more

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Alannah LejeuneDepartment of Microbiology, New York University School of Medicine, New York, United States.
Chunyi ZhouDepartment of Microbiology, New York University School of Medicine, New York, United States.
Defne ErcelenDepartment of Medicine, Division of Gastroenterology and Hepatology, New York University Langone Health, New York, United States.
Gregory PutzelDepartment of Microbiology, New York University School of Medicine, New York, United States.
Xiaomin YaoDepartment of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, United States.
Alyson R GuyNYU-Regeneron Veterinary Postdoctoral Training Program in Laboratory Animal Medicine, Division of Comparative Medicine, New York University School of Medicine, New York, United States.
Miranda PawlineDepartment of Medicine, Division of Gastroenterology and Hepatology, New York University Langone Health, New York, United States.
Magdalena PodkowikDepartment of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, United States.
Alejandro PirontiDepartment of Microbiology, New York University School of Medicine, New York, United States.
Victor J TorresDepartment of Microbiology, New York University School of Medicine, New York, United States.ORCID https://orcid.org/0000-0002-7126-0489
Bo ShopsinDepartment of Microbiology, New York University School of Medicine, New York, United States.ORCID https://orcid.org/0009-0001-7729-8584
Ken CadwellDepartment of Medicine, Division of Gastroenterology and Hepatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID https://orcid.org/0000-0002-5860-0661

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GARY D. WU · 1997 to 2026
$32.5M
Diabetes, Digestive, and Kidney Diseases Extramural ResearchR01DK093668 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2011 to 2026
$7.3M
Redefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6M
The role of autophagy gene Atg16L1 in allogeneic hematopoietic stem cell transplantation - Resubmission - 1R01HL123340 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA, VAN DEN BRINK, MARCEL R M · 2015 to 2022
$5.2M
Training Program in Immunology and Inflammation.T32AI100853 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Susan Ruth Schwab · 2012 to 2026
$4.5M
Mechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5M
Interactions between helminth colonization and the gut microbiotaR01AI130945 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CADWELL, KEN HASHIGIWA · 2018 to 2022
$3.3M
Interactions between Trichuris and the gut microbiotaR01AI179896 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell, E. Jane Albert Hubbard · 2024 to 2026
$2.0M
Mechanisms of fungal involvement during intestinal diseaseR01DK124336 · NIDDK · UNIVERSITY OF UTAH · PI ROUND, JUNE LOUISE · 2020 to 2023
$1.8M
NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL123340NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI130945NIAID NIH HHS R01 AI140754NIAID NIH HHS R01 AI179896NIAID NIH HHS T32 AI100853NIDDK NIH HHS P30 DK050306NIDDK NIH HHS R01 DK093668NIDDK NIH HHS R01 DK124336NIH HHS 2T32AI100853-11NIH HHS AI121244NIH HHS AI130945NIH HHS AI140754NIH HHS AI179896NIH HHS DK050306NIH HHS DK093668NIH HHS DK124336NIH HHS HL123340
6 · The paper itself

Abstract

Gastrointestinal (GI) colonization by methicillin-resistant

Indexed as

Gastrointestinal MicrobiomeGastrointestinal TractMethicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsTh17 CellsAnimalsDisease Models, AnimalFemaleInterleukin-17MaleMiceMice, Inbred C57BLSex FactorsInterleukin-17colonization resistanceGI tractimmunologyinflammationmicrobiotamouseMRSAsex hormoneTh17

Identifiers

PMID40197396
PMCPMC11978300

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.