ReviewBiomedical engineering online2025
A review of osteoporotic vertebral fracture animal models.
Review in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Anesthesia for vertebral compression fractures treated with percutaneous kyphoplasty: Comparison of erector spinae plane block, extrapedicular infiltration anesthesia, and conventional local infiltration anesthesia.Acta orthopaedica et traumatologica turcica · 2026Trial
- Toward accessible quantification of bone mineral density: feasibility of radiographic bone aluminum equivalence (RBAE) determined by digital radiography against DEXA and CT in translational sheep model.BMC medical imaging · 2026Article
- Article
- Macrophages in osteoporotic fractures: from immunometabolic mechanisms to precision therapeutic approaches.Frontiers in endocrinology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionOsteoporotic vertebral fractures are a common outcome of osteoporosis, imposing a substantial economic burden. The development of reliable animal models is essential for advancing research. This review examines osteoporotic vertebral fracture models across various animal species.
methodsThe review compares and analyzes the different approaches used to model osteoporotic vertebral fractures in experimental animals, synthesizing the existing design protocols.
resultsRats and sheep are the primary experimental animals utilized in vertebral fracture research. The predominant approach in model design remains the creation of bone defects to simulate vertebral fractures. The spontaneous fracture model is primarily applicable to small species, such as transgenic mice. Rabbits and zebrafish are not suitable for modeling vertebral fractures due to the low cancellous bone content in their lumbar. The bone loss in the lumbar cancellous bone of the dog osteoporosis model is minimal, making it unsuitable for fracture modeling.
conclusionsThe bone defect model remains the most widely used approach for osteoporotic vertebral fractures. However, the stress compression model shows promise as a potential focal point for future investigations.
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Registered trials
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