ArticleItalian journal of pediatrics2025
Risk factors and mortality in children with severe pertussis: the role of exchange transfusion in a PICU.
Article in Italian journal of pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis:Sultan Qaboos University medical journal · 2025Pooled it
- Therapeutic leukapheresis with severe pertussis: evaluating efficacy, feasibility, and safety.BMC pediatrics · 2026Article
- Epidemiological burden of pertussis in children in Asia: a review of 1990-2021 data and future projections.Translational pediatrics · 2026Article
- Clinical features, disease severity, and outcomes of pertussis in hospitalized children: A retrospective study from Serbia.PloS one · 2026Article
- Practice variability in the management of critical pertussis: a multicenter survey of pediatric intensivists in the Arabian Gulf Cooperation Council region.Frontiers in pediatrics · 2026Article
- Factors associated with pertussis infection and suspected cases in the Aseer Region, Saudi Arabia: a retrospective cross-sectional analysis study.Frontiers in public health · 2026Article
- Clinical characteristics and prognosis of exchange transfusion in infants with severe pertussis.BMC pediatrics · 2025Article
- Article
- A retrospective study on pediatric pertussis: comprehensive evaluation of symptoms, laboratory indicators, and diagnostic efficacy of case definitions.Frontiers in cellular and infection microbiology · 2025Article
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5 authors.
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Abstract
objectiveAlthough multiple risk factors have been reported for adverse outcomes in children with severe pertussis, their predictive values and the benefits of interventions such as exchange transfusion remain poorly understood. Therefore, we aimed to comprehensively evaluate the risk factors associated with mortality in children with severe pertussis and assess the potential benefits of exchange transfusion therapy.
methodsA retrospective analysis of 170 pertussis patients admitted to the Pediatric Intensive Care Unit (PICU) between January 2018 and June 2024 was performed.
resultsAmong the 170 patients, 38 (22.35%) died. The death group exhibited significantly higher white blood cell (WBC) counts (67.31 vs. 28.41 × 10^9/L, P < 0.001), neutrophils (29.95 vs. 11.61 × 10^9/L, P < 0.001), and C-reactive protein (CRP) (29 vs. 8 mg/L, P < 0.001). Additionally, sepsis (39.47% vs. 9.09%, P < 0.001), shock (63.16% vs. 6.06%, P < 0.001), ARDS (23.68% vs. 2.27%, P < 0.001), and acute kidney injury (21.05% vs. 0.76%, P < 0.001) were more prevalent in the death group. ROC analysis showed that WBC counts had a predictive value for mortality (AUC = 0.75, sensitivity = 0.78, specificity = 0.68), with an optimal cutoff of 48.58 × 10^9/L.
conclusionHigh WBC counts are significantly correlated with increased mortality risk in severe pertussis children, with a threshold of 48.58 × 10^9/L marking high risk. Although exchange transfusion can reduce WBC counts and improve symptoms, its benefit is limited in patients with severe secondary infections, necessitating tailored treatment strategies.
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