Evidence map›Paper›PMID 40197198›Full record

ArticleCombinatorial chemistry & high throughput screening2026

The Gut Microbiome and Metabolomics Profiles of Dust-exposed Rats.

Xi Shen, Miaomiao Wang, Shasha Pei, Shuyu Xiao, Kun Xiao, Jinlong Li, Xiaoming Li, Qingan Xia, Heliang Liu, Fuhai Shen

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Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

10 authors.

Xi ShenHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Miaomiao WangHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Shasha PeiHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Shuyu XiaoTangshan Center of Disease Control and Prevention, Tangshan, Hebei, 063000, P.R. China.
Kun XiaoHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Jinlong LiHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Xiaoming LiHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Qingan XiaTangshan Gongren Hospital, Tangshan, Hebei, 063000, P.R. China.
Heliang LiuHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.
Fuhai ShenHebei Province Key Laboratory of Occupational Health and Safety for Coal Industry, School of Public Health, North China University of Science and Technology, Tangshan, Hebei, 063210, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLimited treatments for silicosis necessitate further study of pneumoconiosis characteristics and pathophysiology. This study employs metabolomics to investigate metabolite changes and identify biomarkers for understanding pneumoconiosis pathogenesis.

methods18 healthy SPF male SD rats were divided into three groups: control, coal dust, and silica. Rats were exposed to coal dust, silica, or sterile saline for 8 weeks, after which blood, lung tissue, and feces were collected. Lung pathology was assessed, and inflammatory factors (IL-6, IL-11) were measured. 16S rDNA sequencing and UHPLC-QTOFMS metabolomics were used to analyze intestinal flora and fecal metabolites.

resultsAfter 8 weeks of dust exposure, silica-exposed rats showed significantly reduced weight and elevated serum IL-6 and IL-11 levels compared to controls (P < 0.05). Lung tissue pathology revealed silica group rats exhibited lung damage, intensified inflammation, and silicon nodule formation. Coal dust group rats showed lung tissue changes with fibroblast aggregation. ? diversity analysis showed decreased Shannon index and increased Simpson index in the coal dust group, and a decreased Simpson index in the silica group. ? diversity analysis confirmed significant differences in gut microbiota between dustexposed groups and controls. Metabolomics identified 11 differential metabolites in rat feces, meeting criteria of Fold change > 2, VIP > 1, and P < 0.05. DISCUSSION: Dust exposure disrupts intestinal flora and metabolic state, with potential metabolic markers identified in both coal dust and silica groups, implicating fructose and mannose metabolism in coal dust exposure and sphingolipid metabolism in silica exposure.

Indexed as

DustGastrointestinal MicrobiomeMetabolomicsAnimalsCoalLungMaleRatsRats, Sprague-DawleySilicon DioxideCoalDustSilicon Dioxideinflammatory factorsintestinal florametabolomicsPneumoconiosispotential biomarkerssilica exposure

Identifiers

PMID40197198

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