Evidence map›Paper›PMID 40197193›Full record

ReviewCurrent pharmaceutical biotechnology2026

Detailed Comprehensive Review on Advancement of Cubosomes and their Currently Available Applications.

Raghwendra R Waghmode, Pranay Wal, Seshadri Nalla, Praneeth Ivan Joel Fnu, Virat Kumar Khatri, Pravin Kumar Darji, Binit Patel, Ankita Wal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pharmaceutical biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Raghwendra R WaghmodeKrishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed To Be University), Karad, 415539, Maharashtra, India.
Pranay WalPSIT-Pranveer Singh Institute of Technology (Pharmacy) NH19 Kanpur Agra Highway, Bhaunti, Kanpur, India.
Seshadri NallaLamar University, 4400 S M king Jr PKWY, Beaumont, Texas, 77705, USA.
Praneeth Ivan Joel FnuResearch Chemist (Analytical Sciences), Exemplify Biopharma Inc., Cranbury, New Jersey, 08512, USA.
Virat Kumar KhatriDepartment of Pharmacy, Hemchandracharya North Gujarat University, Patan, Gujarat, 384265, India.
Pravin Kumar DarjiResearch Chemist (Analytical Sciences), Exemplify Biopharma Inc., Cranbury, New Jersey, 08512, USA.
Binit PatelDepartment of Analytical Research and development, Hovione, East Windsor, New Jersey, 08520, USA.ORCID 0000-0003-4633-0411
Ankita WalPSIT-Pranveer Singh Institute of Technology (Pharmacy) NH19 Kanpur Agra Highway, Bhaunti, Kanpur, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cubosomes, nanostructured lipid-based carriers, exhibit a promising potential in drug delivery due to their unique structure, which integrates amphiphilic lipids and polymer-based stabilizers. This review examines the scientific principles of digestion relevant to cubosome function, their structural and compositional aspects, and various processing methods. We also explore potential distribution pathways, drug delivery strategies, and therapeutic applications, including cancer therapy, antimicrobial therapy, vaccine delivery, ocular and dermatological applications, and transdermal delivery. Notably, some challenges still hinder the clinical application of cubosome products, which this review addresses. This paper aims to provide an in-depth discussion on cubosomes, encompassing their composition, theories, processing techniques, and the diverse administration routes that make them a versatile option for targeted drug delivery. A bibliographic review was conducted using major electronic databases (PubMed, ScienceDirect, Scopus, Google Scholar, Springer, and Wiley) along with offline and online academic libraries for comprehensive data collection. Cubosomes, as innovative lipid-based nanotechnology similar to liposomes and niosomes, possess significant potential due to their unique bioadhesive properties, thermodynamic stability, and capability to encapsulate a variety of compounds. Composed typically of glyceryl monooleate and Phytantriol with a stabilizer, cubosomes enable sustained and targeted release, suggesting a broad range of applications. Further advancements are needed to address current limitations in their practical application.

Indexed as

Drug CarriersDrug Delivery SystemsLipidsNanostructuresAnimalsHumansDrug CarriersLipidscomponentCubosomesliposomesproperties and potential applicationstructuretheories

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.