Evidence map›Paper›PMID 40197162›Full record

ArticlemSphere2025

Adam M Nock, Tina R Clark, Sarah L Anzick, Elisabeth A Meyer, Rebecca Miller, Myndi G Holbrook, Stacy Ricklefs, Craig Martens, Justin Lack, Ted Hackstadt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Hybrid capture RNA-seq defines temporal gene expression inbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam M NockHost-Parasite Interaction Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Tina R ClarkHost-Parasite Interaction Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Sarah L AnzickGenomics Research Section, Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA.
Elisabeth A MeyerIntegrated Data Science Section, Research Technologies Branch, NIAID, NIH, Bethesda, Maryland, USA.
Rebecca MillerHost-Parasite Interaction Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.
Myndi G HolbrookGenomics Research Section, Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA.
Stacy RicklefsGenomics Research Section, Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA.
Craig MartensGenomics Research Section, Research Technologies Branch, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, USA.
Justin LackIntegrated Data Science Section, Research Technologies Branch, NIAID, NIH, Bethesda, Maryland, USA.
Ted HackstadtHost-Parasite Interaction Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA.ORCID 0000-0003-1367-5528

Funding

Biology of RickettsiaZ01AI000977 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI HACKSTADT, DAVID (TED) · 2006 to 2008
$1.7M
Intramural NIH HHS Z01 AI000977NHLBI NIH HHS Z01-AI000977
6 · The paper itself

Abstract

The recently described rickettsial protein RoaM (regulator of actin-based motility) negatively regulates the production of actin tails, and its abrogation induces hyper-spreading behavior in many laboratory-adapted strains of IMPORTANCE: RoaM was previously shown to repress the production of actin tails by unknown mechanisms. The

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialRickettsia rickettsiiAnimalsDown-RegulationBacterial Proteinsenvironmental signalinggene expressionRickettsiatranscriptomics

Identifiers

PMID40197162
PMCPMC12039225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.