Prevalence of HPV infection and cervical lesions among women with pelvic organ prolapse and implications for preoperative evaluation.

Yanjun Ge, Fan Wu, Yuchen Zhang, Xintao Wang, Guizhu Wu

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Yanjun Ge *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699 Gaokexi Road, Shanghai, 200092, China.

Fan Wu *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699 Gaokexi Road, Shanghai, 200092, China.

Yuchen Zhang *Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699 Gaokexi Road, Shanghai, 200092, China.

Xintao WangShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699 Gaokexi Road, Shanghai, 200092, China. gomuqq@163.com.

Guizhu WuShanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No.2699 Gaokexi Road, Shanghai, 200092, China. wugz6666@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to learn the sketch of HPV infection and cervical lesions including squamous intraepithelial lesions (SIL) and cervical cancer in the population of patients with pelvic organ prolapse and to attempt to provide them with recommendations for preoperative cervical evaluation.

methodsThis was a retrospective analysis of HPV status, cervical cytology, colposcopic results and histopathology in 1292 patients with Pelvic Organ Prolapse (POP) indicated for hysterectomy over a period of more than 5 years.

resultsOf the 1292 patients, 95 (7.4%) patients tested positive for HPV infection. Among these patients with HPV infection, abnormal Thinprep cytologic test (TCT) results were found in 43 (45.3%) patients and abnormal histopathology were found in 43 (45.3%) patients. Among the 40 patients with normal TCT and positive HPV infection (excluding HPV16/18), 3 cases of unexpected LSIL and one case of unexpected HSIL were identified accidentally. Among POP patients with normal TCT and negative HPV results, 6 cases of LSIL and one case of HSIL, as well as 3 cases of grade I endometrioid endometrial adenocarcinoma and 3 cases of complex atypical hyperplasia of endometrium were accidentally detected in postoperative histopathology.

conclusionsPOP patients are not at higher risk of HPV infection but women with POP and positive HPV infection are at higher risk of cytologic abnormalities or cervical lesions than non-POP population. Colposcopy is recommended as part of the preoperative examination of POP patients to rule out cervical lesions, especially those with HPV infection.

Indexed as

Papillomavirus InfectionsPelvic Organ ProlapsePreoperative CareUterine Cervical DiseasesAgedFemaleHumansHysterectomyMiddle AgedPrevalenceRetrospective StudiesUterine Cervical NeoplasmsHPV infectionPelvic organ prolapsePreoperative examinationSquamous intraepithelial lesions

Identifiers

PMID40197139

DOI10.1186/s12885-025-14049-4

PMCPMC11974025

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