Evidence map›Paper›PMID 40197108›Full record

Observational studyFuture oncology (London, England)2025

Localized and diffuse tenosynovial giant cell tumor: real-world results from a patient observational registry.

Sydney Stern, Patrick F McKenzie, Nicholas Bernthal, Shannon O'Neill, Emanuela Palmerini, R Lor Randall, William Tap, Thomas Scharschmidt, Sara Rothschild

Abstract readObservational Study
In one paragraph

Observational study in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sydney SternTGCT Support/Life Raft Group, Wayne, NJ, USA.ORCID 0000-0002-1479-605X
Patrick F McKenzieDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA, USA.
Nicholas BernthalDivision of Musculoskeletal Oncology, David Geffen School of Medicine at UCLA, Santa Monica, CA, USA.
Shannon O'NeillQueen's School of Medicine, Kingston, Ontario, Canada.
Emanuela PalmeriniDepartment of Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, Bologna, Italy.
R Lor RandallDepartment of Orthopaedic Surgery, University of California Davis, Sacramento, CA, USA.
William TapMemorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA.
Thomas ScharschmidtDepartment of Orthopaedic Surgery, Nationwide Children's Hospital, Columbus, OH, USA.
Sara RothschildTGCT Support/Life Raft Group, Wayne, NJ, USA.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundTenosynovial Giant Cell Tumor (TGCT) is a rare, locally aggressive neoplasm that adversely impact patients' physical function and quality of life (QoL). This cross-sectional analysis leverages real-world data from the TGCT Support Patient Registry to elucidate the patient experience with TGCT and the disease burden across healthcare systems. RESEARCH DESIGN AND

methodsA total of 497 patients from 32 countries, 71.4% (

resultsA majority of patients (61.2%,

conclusionGreater awareness of TGCT among HCPs is needed to facilitate diagnosis and referral to multidisciplinary teams is warranted to reduce recurrence rates, number of surgical interventions, and improve QoL.

Indexed as

Giant Cell Tumor of Tendon SheathNeoplasm Recurrence, LocalAdolescentAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedQuality of LifeRegistriesYoung Adultdiagnosispatient registryquality of lifereal-world evidenceSarcomasolid tumors

Identifiers

PMID40197108
PMCPMC12077479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.