Evidence map›Paper›PMID 40197062›Full record

ArticlemBio2025

Larval zebrafish burn wound infection model reveals conserved innate immune responses against diverse pathogenic fungi.

Nayanna M Mercado Soto, Adam Horn, Nancy P Keller, Anna Huttenlocher, Andrew S Wagner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Loss of Fgr41 inInfection and immunity · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Nayanna M Mercado SotoDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0003-3135-9086
Adam HornDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4386-9473
Anna HuttenlocherDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-7940-6254
Andrew S WagnerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-6777-4006

Funding

Cell migration and wound repairR35GM118027 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher · 2016 to 2026
$7.5M
Mechanoregulation of Basal Keratinocyte Migration in Wounded TissueK99GM147303 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HORN, ADAM · 2022 to 2023
$208k
Development and characterization of human iPSC-derived neutrophil therapies against pathogenic AspergilliF32AI183696 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WAGNER, ANDREW · 2024 to 2024
$50k
National Institute of Allergy and Infectious Diseases F32AI183696-01NIAID NIH HHS F32 AI183696NIGMS NIH HHS K99 GM147303NIGMS NIH HHS K99GM147303NIGMS NIH HHS R35 GM118027NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) DGE-2137424
6 · The paper itself

Abstract

Secondary fungal infections represent a major complication following thermal injuries. However, the mechanisms of fungal colonization of burn tissue and how the host subsequently responds to fungi within this niche remain unclear. We have previously reported a zebrafish model of thermal injury that recapitulates many of the features of human burn wounds. Here, we characterize host-fungal interaction dynamics within the burn wound niche using two of the most common fungal pathogens isolated from burn injuries,

Indexed as

BurnsCandida albicansImmunity, InnateWound InfectionZebrafishAnimalsAnimals, Genetically ModifiedAspergillus fumigatusCandidiasisDisease Models, AnimalHost-Pathogen InteractionsLarvaMacrophagesNeutrophilsAspergillus fumigatusburn woundCandida albicansfungiinnate immunityzebrafishβ(1,3)-glucan

Identifiers

PMID40197062
PMCPMC12077223

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.