Evidence map›Paper›PMID 40196923›Full record

ReviewChemSusChem2025

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

Johannes Schwan, Merlin Kleoff, Gesa H Dreyhsig, Patrick Voßnacker, Traute Fiedler, Marian Rosental, Sebastian Riedel

Abstract readReview
In one paragraph

Review in ChemSusChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Separation and Valorization of Chlorine From Tail Gas Streams.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Johannes SchwanUmweltbundesamt, Section III 2.1, Wörlitzer Platz 1, 06844, Dessau-Roßlau, Germany.
Merlin KleoffFachbereich für Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.
Gesa H DreyhsigFachbereich für Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.
Patrick VoßnackerFachbereich für Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.
Traute FiedlerUmweltbundesamt, Section III 2.1, Wörlitzer Platz 1, 06844, Dessau-Roßlau, Germany.
Marian RosentalInstitut für Energie- und Umweltforschung Heidelberg gGmbH, Wilckensstraße 3, 69120, Heidelberg, Germany.
Sebastian RiedelFachbereich für Biologie, Chemie, Pharmazie, Institut für Chemie und Biochemie - Anorganische Chemie, Freie Universität Berlin, Fabeckstr. 34/36, 14195, Berlin, Germany.ORCID https://orcid.org/0000-0003-4552-5719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review critically examines the dual nature of chlorine as both an indispensable base chemical and a potential risk. Chlorine and its byproduct hydrogen chloride play essential roles in the production of pharmaceuticals, plastics, agrochemicals, and disinfectants. However, their inherent toxicity, risks of handling, and environmental impacts necessitate a reassessment of their use and sustainability. The review explores emerging and established chlorine-free technologies, such as the hydrogen peroxide to propylene oxide process and phosgene-free routes for polycarbonate production, evaluating their potential to reduce reliance on chlorine. For applications where chlorine remains indispensable, innovations such as trichloride- and bichloride-based ionic liquids provide safer storage and handling options for chlorine and hydrogen chloride, respectively. These ionic liquids not only enhance safety but also support renewable energy integration through their potential as indirect energy storage solutions. While chlorine is unlikely to be fully replaced in the near future, ongoing innovations in chlorine-free processes and safer technologies may redefine its industrial use, contributing to a more sustainable and secure chemical industry.

Indexed as

chlorineenvironmental chemistriesindustrial chemistriesionic liquidssustainable chemistries

Identifiers

PMID40196923
PMCPMC12232123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.