Evidence map›Paper›PMID 40196885›Full record

ArticleJournal of the American Geriatrics Society2025

Incidence of Frailty, Dementia, and Disability Among Community-Living Older Americans According to County-Level Disadvantage.

Yi Wang, Emma X Zang, Kendra Davis-Plourde, Brent Vander Wyk, Thomas M Gill, Robert D Becher

Abstract read
In one paragraph

Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi WangDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0003-4257-606X
Emma X ZangDepartment of Sociology, Yale University, New Haven, Connecticut, USA.
Kendra Davis-PlourdeDepartment of Biostatistics, Yale School of Public Health, New Haven, Connecticut, USA.ORCID 0000-0001-6654-0710
Brent Vander WykDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Thomas M GillDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID 0000-0002-6450-0368
Robert D BecherDepartment of Surgery, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

The National Health and Trends StudyU01AG032947 · NIA · JOHNS HOPKINS UNIVERSITY · PI VICKI A. FREEDMAN, JENNIFER ANN SCHRACK · 2008 to 2026
$169.4M
Yale Study Support Suite (YES3): Dashboard and Web Portal Software Supporting Research Workflow through integrated, customizable REDCap External ModulesP30AG021342 · NIA · YALE UNIVERSITY · PI Lauren Ferrante · 2002 to 2026
$37.9M
A Multifactorial Approach to Evaluating Disparities in Outcomes after Major Surgery in Disadvantaged Older PersonsR01MD017298 · NIMHD · YALE UNIVERSITY · PI BECHER, ROBERT DAVID, GILL, THOMAS MICHAEL · 2022 to 2025
$2.6M
NIA NIH HHS P30 AG021342NIA NIH HHS U01 AG032947NIA NIH HHS U01AG032947NIMHD NIH HHS R01 MD017298NIMHD NIH HHS R01MD017298Yale Claude D. Pepper Older Americans Independence Center P30AG021342
6 · The paper itself

Abstract

backgroundCounty-level contextual disadvantage is a novel social determinant of health (SDOH) for older persons. No prior study has evaluated the national incidence of geriatric conditions according to county-level contextual disadvantage among older persons. Our objective was to estimate the incidence of frailty, probable dementia, and disability over a 5-year period on the basis of county-level contextual disadvantage among community-living older Americans.

methodsThis prospective, nationally representative longitudinal study used data from the 2015 cohort of the National Health and Aging Trends Study (NHATS), linked to various publicly available, geographically based contextual datasets. County-level disadvantage was assessed using the Geriatric Index of County-Level Multi-Dimensional Contextual Disadvantage (GERi-County), which included nine contextual indicators from these linked datasets. Data on frailty, probable dementia, and activities of daily living (ADL) disability were obtained from the NHATS annual assessments (2015-2020).

resultsTotally 7499 participants were included in the analysis, representing 40,728,543 community-living older Americans. The 5-year incidence rates per 1000 person-years were significantly higher in the disadvantaged compared to the non-disadvantaged counties: 52.8 (95% confidence interval (CI), 41.6-64.0) versus 40.3 (95% CI, 37.2-43.3) for frailty; 29.9 (95% CI, 25.4-34.3) versus 21.2 (95% CI, 19.0-23.4) for probable dementia; and 78.1 (95% CI, 70.2-86.0) versus 62.5 (95% CI, 58.2-66.8) for ADL disability. For participants who lived versus did not live in disadvantaged counties, the age- and sex-adjusted HRs were 1.38 (95% CI, 1.08-1.75) for frailty, 1.53 (95% CI, 1.25-1.86) for probable dementia, and 1.30 (95% CI, 1.13-1.49) for ADL disability.

conclusionsCommunity-living older Americans who reside in disadvantaged counties have a higher incidence of frailty, probable dementia, and ADL disability over a 5-year follow-up period compared to their non-disadvantaged counterparts. Findings underscore the vital, underappreciated role that county-level social contextual disadvantage plays on clinically meaningful outcomes in older persons in the U.S.

Indexed as

DementiaFrail ElderlyFrailtyIndependent LivingPersons with DisabilitiesActivities of Daily LivingAgedAged, 80 and overFemaleGeriatric AssessmentHumansIncidenceLongitudinal StudiesMaleProspective StudiesSocial Determinants of Healthcounty‐level disadvantagegeriatric conditionslongitudinal studysocial determinants of health

Identifiers

PMID40196885
PMCPMC12213133

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.