ReviewFrontiers in cell and developmental biology2025
The role of the Hippo/YAP pathway in the physiological activities and lesions of lens epithelial cells.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Quercetin Inhibits Orthodontic Tooth Movement-Associated Periodontitis by Regulating Macrophage Aerobic Glycolysis Through the IL-17/Hippo/YAP Axis.Clinical and experimental dental research · 2026Article
- Lens aging and disease: Molecular mechanisms, functional consequences, and pharmacological implications.Progress in retinal and eye research · 2026Review
- Sodium selenite promotes apoptosis and augments autophagic flux in cervical cancer cells by activating the YAP-Hippo signaling pathway.Translational cancer research · 2026Article
- Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities.Frontiers in cell and developmental biology · 2026Review
- The protective role of quercetin in cataract lenses and its mechanisms related to the hippo signaling pathway.International ophthalmology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Hippo/YAP pathway is a signaling pathway that plays an important role in cell proliferation, survival, differentiation, cell fate determination, organ size, and tissue homeostasis. Lens epithelial cells (LECs), located on the anterior surface of the lens, are the parental cells responsible for growth and development of the transparent ocular lens. During lens development, LECs undergo a process of differentiation where they exit the cell cycle and transform into lens fiber cells (LFCs), which constitute the majority of the lens structure. YAP is involved in the proliferation and differentiation of LECs, the maintenance of nuclear morphology, cell polarity, cell apical polarity complex, and connexin morphology. The role of the ordered arrangement of LFCs has been demonstrated in several animal studies, and
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