Exploring the role of strontium-based nanoparticles in modulating bone regeneration and antimicrobial resistance: a public health perspective.

Strontium-based nanoparticles (SrNPs) have emerged as a versatile and promising class of nanomaterials with a wide range of potential applications in healthcare, particularly in the fields of bone regeneration and combating antimicrobial resistance (AMR). Recent research has highlighted the unique properties of SrNPs, including their ability to promote osteogenesis, enhance bone healing, and exhibit strong antimicrobial activity against multidrug-resistant pathogens. These attributes position SrNPs as innovative therapeutic agents with the potential to address challenges such as osteoporosis, bone infections, and the growing global AMR crisis. This comprehensive review critically examines the dual functional potential of SrNPs by analyzing their synthesis methods, physicochemical properties, biological interactions, and translational applications in orthopedic and antimicrobial therapies. Specifically, the review emphasizes SrNPs' ability to enhance bone density, accelerate fracture healing, and reduce the economic burden associated with prolonged treatment and rehabilitation for bone-related diseases. Furthermore, their novel application as antimicrobial agents is explored, highlighting their ability to target bacterial metabolic pathways and combat the rise of antibiotic resistance. The review focuses on the synthesis methods used for SrNPs, particularly co-precipitation, hydrothermal synthesis, and sol-gel techniques. Each method is explored for its ability to produce SrNPs with controlled size, shape, and functionality, while addressing their scalability, cost-effectiveness, and environmental impact. Additionally, the toxicological risks associated with SrNPs are also explored, emphasizing the need for comprehensive preclinical and clinical evaluations to ensure safety for humans and ecosystems. The regulatory and ethical landscape of SrNPs highlights the need for global safety protocols, equitable access, and international cooperation to ensure ethical nanotechnology use. Environmental fate studies address bioaccumulation risks and ecological concerns. This review identifies opportunities and challenges in advancing bone regenerative medicine and combating AMR while emphasizing sustainable and ethical SrNP development for researchers, policymakers, and stakeholders.