ArticleCancer innovation2025
Prognostic Effect of Neck Dissection and Risk Factors for Occult Lymph Node Metastasis in cN0 Parotid Carcinoma.
Article in Cancer innovation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The role of elective neck dissection in parotid acinic cell carcinoma: a systematic review.Oral and maxillofacial surgery · 2026Pooled it
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to explore the prognostic effect of neck dissection and to identify risk factors associated with occult lymph node metastasis (OLNM) in clinically node-negative (cN0) parotid carcinoma (PC). Methods: A retrospective analysis was conducted on cN0 PC patients who underwent primary surgery at the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, between 2012 and 2022. Kaplan-Meier (KM) survival analyses were carried out to evaluate differences in progression-free survival (PFS) and overall survival (OS) between patients undergoing neck dissection and those who did not. Clinical variables associated with OLNM in the neck dissection group were assessed using univariate and multivariate logistic regression analyses. Results: Among 472 PC patients, 133 were classified as cN0 following initial surgery, of whom 75 (56.4%) underwent neck dissection. Pathological lymph node metastases were confirmed in 20 (26.7%) patients in the neck dissection cohort. Poor tumor differentiation was identified as an independent risk factor for OLNM ( Conclusion: Poorly differentiated tumors in cN0 PC are independently associated with a higher risk of OLNM. While prophylactic neck dissection may enhance PFS in patients with higher grade or poorly differentiated tumors, it does not confer a survival benefit in terms of OS. These findings support the selective use of neck dissection in patients with higher risk tumor profiles.
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