Evidence map›Paper›PMID 40196708›Full record

ArticleConservation physiology2025

Etorphine induces pathophysiology in immobilized white rhinoceros through sympathomimesis that is attenuated by butorphanol.

Jordyn M Boesch, Robin D Gleed, Peter E Buss, Adrian S W Tordiffe, Gareth E Zeiler, Michele A Miller, Francois Viljoen, Brian H Harvey, Stephen A Parry, Leith C R Meyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Conservation physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jordyn M BoeschDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, 930 Campus Road, Ithaca, New York 14853, USA.ORCID https://orcid.org/0000-0002-2032-1202
Robin D GleedDepartment of Clinical Sciences, College of Veterinary Medicine, Cornell University, 930 Campus Road, Ithaca, New York 14853, USA.
Peter E BussVeterinary Wildlife Services, South African National Parks, Kruger National Park, Private Bag X402, Skukuza 1350, South Africa.
Adrian S W TordiffeCentre for Veterinary Wildlife Research, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa.ORCID https://orcid.org/0000-0001-5416-3153
Gareth E ZeilerDepartment of Companion Animal Clinical Studies, Faculty of Veterinary Science, University of Pretoria, OVAH-building, Onderstepoort Campus, Private Bag X04, Onderstepoort 0110, South Africa.
Michele A MillerSouth African Medical Research Council (MRC) Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa.
Francois ViljoenCentre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Division of Pharmacology), North-West University (Potchefstroom Campus), Universiteit Street, Potchefstroom 2531, South Africa.
Brian H HarveyCentre of Excellence for Pharmaceutical Sciences, School of Pharmacy (Division of Pharmacology), North-West University (Potchefstroom Campus), Universiteit Street, Potchefstroom 2531, South Africa.
Stephen A ParryCornell University Statistical Consulting Unit, Cornell University, Savage Hall, 244 Garden Avenue, Ithaca, New York 14853, USA.
Leith C R MeyerCentre for Veterinary Wildlife Research, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

White rhinoceros are a sentinel species for important ecosystems in southern Africa. Their conservation requires active management of their population, which, in turn, requires immobilization of individuals with an ultra-potent opioid such as etorphine. Unfortunately, when immobilized with etorphine, they develop severe hypoxaemia that may contribute to morbidity and mortality. We hypothesized that (i) etorphine causes sympathetic upregulation that is responsible for physiological complications that produce hypoxaemia and (ii) butorphanol, a partial μ opioid agonist, mitigates sympathetic upregulation, thereby improving arterial oxygen content (CaO

Indexed as

ButorphanolCeratotherium simumetorphinehypoxaemianoradrenalinesympathetic

Identifiers

PMID40196708
PMCPMC11974248

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.